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miR-218 microRNA precursor is a small non-coding RNA that regulates gene expression by antisense binding.
miR-218 appears to be a vertebrate specific microRNA and has now been predicted and experimentally confirmed in a wide range of vertebrate species. The extents of the hairpin precursors are not known. In this case the mature sequence in excised from the 5'arm of the hairpin.
miR-218, along with miR-585, has been found to be silenced by DNA methylation in oral squamous cell carcinoma. It is also downregulated in Nasopharyngeal carcinoma, with artificially-induced expression serving to slow tumour growth. miR-218 has also been found to have tumour suppressing qualities in bladder cancer cells.
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miR-218 microRNA precursor is a small non-coding RNA that regulates gene expression by antisense binding.
miR-218 appears to be a vertebrate specific microRNA and has now been predicted and experimentally confirmed in a wide range of vertebrate species.[1] The extents of the hairpin precursors are not known. In this case the mature sequence in excised from the 5'arm of the hairpin.
miR-218, along with miR-585, has been found to be silenced by DNA methylation in oral squamous cell carcinoma.[2] It is also downregulated in Nasopharyngeal carcinoma, with artificially-induced expression serving to slow tumour growth.[3] miR-218 has also been found to have tumour suppressing qualities in bladder cancer cells.[4]
[edit] References
- ^ "miRNA gene family: mir-218". mirBASE. The University of Manchester. http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000026.
- ^ Uesugi, A; Kozaki, K, Tsuruta, T, Furuta, M, Morita, K, Imoto, I, Omura, K, Inazawa, J (2011 Sep 1). "The Tumor Suppressive MicroRNA miR-218 Targets the mTOR Component Rictor and Inhibits AKT Phosphorylation in Oral Cancer.". Cancer Research 71 (17): 5765–78. doi:10.1158/0008-5472.CAN-11-0368. PMID 21795477.
- ^ Alajez, NM; Lenarduzzi, M, Ito, E, Hui, AB, Shi, W, Bruce, J, Yue, S, Huang, SH, Xu, W, Waldron, J, O'Sullivan, B, Liu, FF (2011 Mar 15). "MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway.". Cancer Research 71 (6): 2381–91. doi:10.1158/0008-5472.CAN-10-2754. PMID 21385904.
- ^ Tatarano, S; Chiyomaru, T, Kawakami, K, Enokida, H, Yoshino, H, Hidaka, H, Yamasaki, T, Kawahara, K, Nishiyama, K, Seki, N, Nakagawa, M (2011 Jul). "miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer.". International journal of oncology 39 (1): 13–21. doi:10.3892/ijo.2011.1012. PMID 21519788.
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