Stem-loop sequence hsa-mir-503

Accession

MI0003188

Symbol

HGNC:MIR503

Description

Homo sapiens miR-503 stem-loop

Gene family

MIPF0000183; mir-503

Stem-loop

      a              u  g  gu     a 
ugcccu gcagcgggaacagu cu ca  gagcg u
|||||| |||||||||||||| || ||  ||||| c
auggga cgucgccuuuguua gg gu  cucgu g
      c              u  g  --     g 

Deep sequencing

9118 reads, 30 experiments

Genome context

• Coordinates (GRCh37.p5): chrX: 133680358-133680428 [-]
• Overlapping transcripts:

  sense

  OTTHUMT00000058369 ; AC004383.4-001; intron 1

  OTTHUMT00000058370 ; AC004383.4-002; intron 1

  OTTHUMT00000058372 ; AC004383.4-004; intron 1

  OTTHUMT00000058369 ; AC004383.4-001; intron 1

  OTTHUMT00000058370 ; AC004383.4-002; intron 1

  OTTHUMT00000058372 ; AC004383.4-004; intron 1

  OTTHUMT00000058370 ; AC004383.4-002; intron 1

  OTTHUMT00000058372 ; AC004383.4-004; intron 1

  OTTHUMT00000058369 ; AC004383.4-001; intron 1

  ENST00000441492 ; AC004383.4-001; intron 1

  ENST00000440570 ; AC004383.4-002; intron 1

  ENST00000414769 ; AC004383.4-004; intron 1

  ENST00000441492 ; AC004383.4-001; intron 1

  ENST00000440570 ; AC004383.4-002; intron 1

  ENST00000414769 ; AC004383.4-004; intron 1

  ENST00000440570 ; AC004383.4-002; intron 1

  ENST00000414769 ; AC004383.4-004; intron 1

  ENST00000441492 ; AC004383.4-001; intron 1

Clustered miRNAs

< 10kb from hsa-mir-503

• hsa-mir-424: chrX: 133680644-133680741 [-]
• hsa-mir-503: chrX: 133680358-133680428 [-]
• hsa-mir-542: chrX: 133675371-133675467 [-]
• hsa-mir-450a-2: chrX: 133674538-133674637 [-]
• hsa-mir-450a-1: chrX: 133674371-133674461 [-]
• hsa-mir-450b: chrX: 133674215-133674292 [-]

Database links

• EMBL: AY882283;AY882283
• ENTREZGENE: 574506;MIR503
• HGNC: 32138;MIR503

Mature sequence hsa-miR-503-5p

• Accession: MIMAT0002874
• Previous IDs: hsa-miR-503
• Sequence: 6 - uagcagcgggaacaguucugcag - 28
• Deep sequencing: 9093 reads, 29 experiments
• Evidence: experimental; array-cloned [1], cloned [2-3], SOLiD [4]
• Validated targets:
  • TARBASE:hsa-miR-503-5p
• Predicted targets:
  • DIANA-MICROT:hsa-miR-503-5p
  • MICRORNA.ORG:hsa-miR-503-5p
  • MIRDB:hsa-miR-503-5p
  • RNA22-HSA:hsa-miR-503-5p
  • TARGETSCAN-VERT:hsa-miR-503

Mature sequence hsa-miR-503-3p

• Accession: MIMAT0022925
• Sequence: 46 - gggguauuguuuccgcugccagg - 68
• Deep sequencing: 24 reads, 4 experiments
• Evidence: experimental; SOLiD [4]

References

1. PMID:15965474 "Identification of hundreds of conserved and nonconserved human microRNAs" Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z Nat Genet. 37:766-770(2005).
2. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:22282338 "Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs" Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F RNA. 18:472-484(2012).