Stem-loop sequence dre-mir-219-2

AccessionMI0001385 (change log)
DescriptionDanio rerio miR-219-2 stem-loop
Gene family MIPF0000044; mir-219
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-219_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology, the microRNA miR-219 was predicted in vertebrates by conservation between human, mouse and pufferfish and cloned in pufferfish. It was later predicted and confirmed experimentally in Drosophila. Homologs of miR-219 have since been predicted or experimentally confirmed in a wide range of species, including the platyhelminth Schmidtea mediterranea, several arthropod species and a wide range of vertebrates (MIPF0000044). The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 5' arm of the hairpin. miR-219 has also been linked with NMDA receptor signalling in humans, and it has been suggested that deregulation of this miRNA can lead to the expression of mental disorders such as schizophrenia.

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   ---------------u   u     aa           ugaaa  -  g 
5'                 gau gucca  cgcaauucuug     ug uc a
                   ||| |||||  |||||||||||     || ||  
3'                 cua caggu  guguuaagagc     ac ag g
   ccucggaggucguugu   -     cc           ---ug  u  c 
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr5: 65101371-65101450 [+]
OTTDART00000060002 ; si:ch211-233f10.7-001; exon 2
ENSDART00000154708 ; si:ch211-233f10.7-001; exon 2
KZ115158.1: 20010-20089 [+]
OTTDART00000060002 ; si:ch211-233f10.7-001; exon 2
ENSDART00000154708 ; si:ch211-233f10.7-001; exon 2
Database links

Mature sequence dre-miR-219-5p

Accession MIMAT0001286
Previous IDsdre-miR-219

1 - 


 - 22

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Evidence experimental; cloned [1]
Database links
Predicted targets


PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
PMID:15937218 "The developmental miRNA profiles of zebrafish as determined by small RNA cloning" Chen PY, Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T Genes Dev. 19:1288-1293(2005).