Stem-loop sequence dre-mir-181a-1

AccessionMI0001380 (change log)
Previous IDsdre-mir-213
DescriptionDanio rerio miR-181a-1 stem-loop
Gene family MIPF0000007; mir-181
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-181_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology miR-181 microRNA precursor is a small non-coding RNA molecule. MicroRNAs (miRNAs) are transcribed as ~70 nucleotide precursors and subsequently processed by the RNase-III type enzyme Dicer to give a ~22 nucleotide mature product. In this case the mature sequence comes from the 5' arm of the precursor. They target and modulate protein expression by inhibiting translation and / or inducing degradation of target messenger RNAs. This new class of genes has recently been shown to play a central role in malignant transformation. miRNA are downregulated in many tumors and thus appear to function as tumor suppressor genes. The mature products miR-181a, miR-181b, miR-181c or miR-181d are thought to have regulatory roles at posttranscriptional level, through complementarity to target mRNAs. miR-181 which has been predicted or experimentally confirmed in a wide number of vertebrate species as rat, zebrafish, and in the pufferfish (see below) (MIPF0000007).

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   guuu   u   u a   u      cu       a    -gag  a 
5'     gcc cag g aca ucaacg  gucggug guuu    cu a
       ||| ||| | ||| ||||||  ||||||| ||||    ||  
3'     cgg guc c ugu aguugc  cagcuac caaa    gg a
   ----   c   c a   u      --       -    aaaa  u 
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Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr22: 22826004-22826087 [-]
Clustered miRNAs
< 10kb from dre-mir-181a-1
dre-mir-181a-1chr22: 22826004-22826087 [-]
dre-mir-181b-3chr22: 22825793-22825877 [-]
Database links

Mature sequence dre-miR-181a-5p

Accession MIMAT0001623
Previous IDsdre-miR-181a

14 - 


 - 36

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Evidence by similarity; MI0001380

Mature sequence dre-miR-181a-3p

Accession MIMAT0001282
Previous IDsdre-miR-213;dre-miR-181a*

56 - 


 - 77

Get sequence
Evidence experimental; cloned [1]
Database links


PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).