Stem-loop sequence hsa-mir-196b

AccessionMI0001150 (change log)
Symbol HGNC:MIR196B
DescriptionHomo sapiens miR-196b stem-loop
Gene family MIPF0000031; mir-196
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-196_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-196 is a non-coding RNA called a microRNA that has been shown to be expressed in human (MI0000238, MI0000279) and mouse (MI0000552, MI0000553). miR-196 appears to be a vertebrate specific microRNA and has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000031). In many species the miRNA appears to be expressed from intergenic regions in HOX gene clusters. The hairpin precursors are predicted based on base pairing and cross-species conservation—their extents are not known. In this case the mature sequence is excised from the 5' arm of the hairpin. It has been suggested that a rare SNP (rs11614913) that overlaps hsa-mir-196a2 has been found to be associated with non-small cell lung carcinoma.

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5'   acugg  ggugau  agguagu uc uguuguuggga    c
     |||||  ||||||  ||||||| || |||||||||||     
3'   ugacu  ucauua  uccguca ag acgacagcucu    c
   gu     --      cu       c  c           cuuu 
Get sequence
Deep sequencing
395020 reads, 2.39e+03 reads per million, 73 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

miR-196b is predicted based on sequence homology to miR-196a [1]. Yekta et al. report that miR-196 miRNAs are expressed from HOX gene clusters in mammals, and that HOX genes in these clusters are targets of miR-196. Indeed, HOXB8 mRNA was shown to be a natural target for miR-196-directed cleavage through a perfectly complementary miR-target site. Other HOX genes have imperfect miR-196 complementary sites indicative of regulation by translational repression [1]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chr7: 27169480-27169563 [-]
OTTHUMT00000134391 ; HOXA3-005; intron 1
OTTHUMT00000358709 ; HOXA3-007; intron 1
OTTHUMT00000134390 ; HOXA3-006; intron 1
OTTHUMT00000059534 ; HOXA4-001; intron 1
OTTHUMT00000358700 ; HOXA4-004; intron 1
OTTHUMT00000358710 ; HOXA3-008; intron 2
OTTHUMT00000473057 ; RP1-170O19.22-001; intron 2
ENST00000522788 ; HOXA3-005; intron 1
ENST00000521779 ; HOXA3-007; intron 1
ENST00000521401 ; HOXA3-006; intron 1
ENST00000360046 ; HOXA4-001; intron 1
ENST00000511914 ; HOXA4-004; intron 1
ENST00000428284 ; HOXA4-201; intron 1
ENST00000518451 ; HOXA3-008; intron 2
ENST00000467897 ; RP1-170O19.22-001; intron 2
OTTHUMT00000407129 ; HOXA-AS2-003; intron 3
ENST00000521159 ; HOXA-AS2-003; intron 3
Database links

Mature sequence hsa-miR-196b-5p

Accession MIMAT0001080
Previous IDshsa-miR-196b

15 - 


 - 36

Get sequence
Deep sequencing393088 reads, 71 experiments
Evidence experimental; cloned [2-3]
Database links
Predicted targets

Mature sequence hsa-miR-196b-3p

Accession MIMAT0009201
Previous IDshsa-miR-196b*

50 - 


 - 71

Get sequence
Deep sequencing1934 reads, 45 experiments
Evidence experimental; 454 [4]
Database links
Predicted targets


PMID:15105502 "MicroRNA-directed cleavage of HOXB8 mRNA" Yekta S, Shih IH, Bartel DP Science. 304:594-596(2004).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).
PMID:19144710 "Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas" Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G J Virol. 83:3333-3341(2009).