Stem-loop sequence rno-mir-206

AccessionMI0000948 (change log)
DescriptionRattus norvegicus miR-206 stem-loop
Gene family MIPF0000038; mir-1
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-1_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-1 microRNA precursor is a small micro RNA that regulates its target protein's expression in the cell. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In humans there are two distinct microRNAs that share an identical mature sequence, these are called miR-1-1 and miR-1-2. These micro RNAs have pivotal roles in development and physiology of muscle tissues including the heart. MiR-1 is known to be involved in important role in heart diseases such as hypertrophy, myocardial infarction, and arrhythmias. Studies have shown that MiR-1 is an important regulator of heart adaption after ischemia or ischaemic stress and it is upregulated in the remote myocardium of patients with myocardial infarction. Also MiR-1 is downregulated in myocardial infarcted tissue compared to healthy heart tissue. Plasma levels of MiR-1 can be used as a sensitive biomarker for myocardial infarction.

Show Wikipedia entry View @ Wikipedia Edit Wikipedia entry
Stem-loop
   --   c  c                     c u     auau 
5'   cuu cc aggccacaugcuucuuuauau c cauag    c
     ||| || ||||||||||||||||||||| | |||||    a
3'   gaa gg uuuggugugugaaggaaugua g guauc    c
   gu   c  u                     a -     gcgu 
Get sequence
Deep sequencing
2502 reads, 92.6 reads per million, 27 experiments
Confidence
Feedback: Do you believe this miRNA is real?
Genome context
Coordinates (Rnor_6.0; GCA_000001895.4) Overlapping transcripts
chr9: 26791764-26791847 [+]
intergenic
Clustered miRNAs
< 10kb from rno-mir-206
rno-mir-206chr9: 26791764-26791847 [+]
rno-mir-133bchr9: 26795649-26795732 [+]
Database links

Mature sequence rno-miR-206-5p

Accession MIMAT0017154
Previous IDsrno-miR-206*
Sequence

13 - 

acaugcuucuuuauauccucau

 - 34

Get sequence
Deep sequencing1 reads, 1 experiments
Evidence experimental; SOLiD [3]
Predicted targets

Mature sequence rno-miR-206-3p

Accession MIMAT0000879
Previous IDsrno-miR-206
Sequence

51 - 

uggaauguaaggaagugugugg

 - 72

Get sequence
Deep sequencing2501 reads, 27 experiments
Evidence experimental; cloned [1-2], SOLiD [3]
Predicted targets

References

1
2
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3
PMID:20403161 "Small RNA expression and strain specificity in the rat" Linsen SE, de Wit E, de Bruijn E, Cuppen E BMC Genomics. 11:249(2010).