Stem-loop sequence rno-mir-181c

AccessionMI0000924 (change log)
DescriptionRattus norvegicus miR-181c stem-loop
Gene family MIPF0000007; mir-181
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-181_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology miR-181 microRNA precursor is a small non-coding RNA molecule. MicroRNAs (miRNAs) are transcribed as ~70 nucleotide precursors and subsequently processed by the RNase-III type enzyme Dicer to give a ~22 nucleotide mature product. In this case the mature sequence comes from the 5' arm of the precursor. They target and modulate protein expression by inhibiting translation and / or inducing degradation of target messenger RNAs. This new class of genes has recently been shown to play a central role in malignant transformation. miRNA are downregulated in many tumors and thus appear to function as tumor suppressor genes. The mature products miR-181a, miR-181b, miR-181c or miR-181d are thought to have regulatory roles at posttranscriptional level, through complementarity to target mRNAs. miR-181 which has been predicted or experimentally confirmed in a wide number of vertebrate species as rat, zebrafish, and in the pufferfish (see below) (MIPF0000007).

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Stem-loop
   ---agaacuug   a  g       gaa        cu       a     ggca 
5'            cca gg uuugggg   cauucaac  gucggug guuug    g
              ||| || |||||||   ||||||||  ||||||| |||||    c
3'            ggu cc gagcccc   gugaguug  cagcuac caaac    u
   cccaccgucaa   -  g       -ag        -c       -     agac 
Get sequence
Deep sequencing
141702 reads, 1.19e+03 reads per million, 39 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Genome context
Coordinates (Rnor_6.0; GCA_000001895.4) Overlapping transcripts
chr19: 25290211-25290316 [-]
intergenic
Clustered miRNAs
< 10kb from rno-mir-181c
rno-mir-181cchr19: 25290211-25290316 [-]
rno-mir-181dchr19: 25290051-25290133 [-]
Database links

Mature sequence rno-miR-181c-5p

Accession MIMAT0000857
Previous IDsrno-miR-181c
Sequence

24 - 

aacauucaaccugucggugagu

 - 45

Get sequence
Deep sequencing123930 reads, 39 experiments
Evidence experimental; cloned [1], SOLiD [2]
Predicted targets

Mature sequence rno-miR-181c-3p

Accession MIMAT0017137
Previous IDsrno-miR-181c*
Sequence

63 - 

accaucgaccguugaguggacc

 - 84

Get sequence
Deep sequencing17772 reads, 39 experiments
Evidence experimental; SOLiD [2]
Predicted targets

References

1
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
2
PMID:20403161 "Small RNA expression and strain specificity in the rat" Linsen SE, de Wit E, de Bruijn E, Cuppen E BMC Genomics. 11:249(2010).