Stem-loop sequence rno-mir-130a

AccessionMI0000903 (change log)
DescriptionRattus norvegicus miR-130a stem-loop
Gene family MIPF0000034; mir-130
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-130_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408), and in human (MI0000448, MI0000748). miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma. It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.

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Stem-loop
   u     -u     ga        c      ug  a  guc   a 
5'  gcugc  ggccg  gcucuuuu acauug  cu cu   uac c
    |||||  |||||  |||||||| ||||||  || ||   |||  
3'  ugaug  ccggc  cgggaaaa uguaac  ga ga   aug g
   -     uu     ua        u      gu  c  gcc   u 
Get sequence
Deep sequencing
31935 reads, 308 reads per million, 39 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Genome context
Coordinates (Rnor_6.0; GCA_000001895.4) Overlapping transcripts
chr3: 72141037-72141124 [-]
sense
ENSRNOT00000009903 ; Smtnl1-201; intron 8
Clustered miRNAs
< 10kb from rno-mir-130a
rno-mir-3590chr3: 72141044-72141117 [+]
rno-mir-130achr3: 72141037-72141124 [-]
Database links

Mature sequence rno-miR-130a-5p

Accession MIMAT0017121
Previous IDsrno-miR-130a*
Sequence

15 - 

gcucuuuucacauugugcuacu

 - 36

Get sequence
Deep sequencing24 reads, 15 experiments
Evidence experimental; SOLiD [5]
Predicted targets

Mature sequence rno-miR-130a-3p

Accession MIMAT0000836
Previous IDsrno-miR-130a
Sequence

55 - 

cagugcaauguuaaaagggcau

 - 76

Get sequence
Deep sequencing31911 reads, 39 experiments
Evidence experimental; cloned [1-4], Northern [1,3], SOLiD [5]
Predicted targets

References

1
PMID:14691248 "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons" Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G Proc Natl Acad Sci U S A. 101:360-365(2004).
2
PMID:15345052 "Microarray analysis of microRNA expression in the developing mammalian brain" Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR Genome Biol. 5:R68(2004).
3
4
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5
PMID:20403161 "Small RNA expression and strain specificity in the rat" Linsen SE, de Wit E, de Bruijn E, Cuppen E BMC Genomics. 11:249(2010).