Stem-loop sequence rno-mir-34c

AccessionMI0000876 (change log)
DescriptionRattus norvegicus miR-34c stem-loop
Gene family MIPF0000039; mir-34
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-34_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The mir-34 microRNA precursor family are non-coding RNA molecules that, in mammals, give rise to three major mature miRNAs. The miR-34 family members were discovered computationally and later verified experimentally. The precursor miRNA stem-loop is processed in the cytoplasm of the cell, with the predominant miR-34 mature sequence excised from the 5' arm of the hairpin. The mature miR-34a is a part of the p53 tumor suppressor network; therefore, it is hypothesized that miR-34 dysregulation is involved in the development of some cancers.

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Stem-loop
        ag     a   a    a     c      c  a 
5' agucu  uuacu ggc gugu guuag ugauug ua u
   |||||  ||||| ||| |||| ||||| |||||| ||  
3' ucaga  aaugg ccg caca caauc acuaac au a
        aa     a   a    c     -      c  g 
Get sequence
Deep sequencing
31942 reads, 5.87e+03 reads per million, 39 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Genome context
Coordinates (Rnor_6.0; GCA_000001895.4) Overlapping transcripts
chr8: 55492024-55492100 [-]
intergenic
Clustered miRNAs
< 10kb from rno-mir-34c
rno-mir-34bchr8: 55492542-55492625 [-]
rno-mir-34cchr8: 55492024-55492100 [-]
Database links

Mature sequence rno-miR-34c-5p

Accession MIMAT0000814
Previous IDsrno-miR-34c
Sequence

13 - 

aggcaguguaguuagcugauugc

 - 35

Get sequence
Deep sequencing31673 reads, 39 experiments
Evidence experimental; cloned [1], SOLiD [2]
Predicted targets

Mature sequence rno-miR-34c-3p

Accession MIMAT0004723
Previous IDsrno-miR-34c*
Sequence

46 - 

aaucacuaaccacacagccagg

 - 67

Get sequence
Deep sequencing269 reads, 22 experiments
Evidence experimental; cloned [1], SOLiD [2]
Predicted targets

References

1
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
2
PMID:20403161 "Small RNA expression and strain specificity in the rat" Linsen SE, de Wit E, de Bruijn E, Cuppen E BMC Genomics. 11:249(2010).