Stem-loop sequence hsa-mir-148b

Symbol HGNC:MIR148B
DescriptionHomo sapiens miR-148b stem-loop
Gene family MIPF0000056; mir-148
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-148/mir-152_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology, miR-148 is a microRNA whose expression has been demonstrated in human (MI0000253), mouse (MI0000550), rat (MI0000616) and zebrafish (MI0002015). miR-148 has also been predicted in chicken (MI0001189). These predicted hairpin precursor sequence are related to those of miR-152, which has been expressed in mouse (MI0000174) and is predicted in human (MI0000462). The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 3' arm of the hairpin.

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   caagcac  uu   a       ug         u  a    ca    gugg u 
5'        ga  agc uuugagg  aaguucugu au cacu  ggcu    c c
          ||  ||| |||||||  ||||||||| || ||||  ||||    | u
3'        cu  ucg aagcucu  uucaagaca ua guga  cuga    g c
   -----au  -u   a       gu         c  c    --    --aa u 
Get sequence
Deep sequencing
62805 reads, 1.1e+03 reads per million, 66 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2]. Its expression was later verified in human [3,4].

Genome context
Coordinates (GRCh38) Overlapping transcripts
chr12: 54337216-54337314 [+]
OTTHUMT00000358865 ; HOXC13-001; intron 1
ENST00000243056 ; HOXC13-001; intron 1
Database links

Mature sequence hsa-miR-148b-5p

Accession MIMAT0004699
Previous IDshsa-miR-148b*

25 - 


 - 46

Get sequence
Deep sequencing518 reads, 24 experiments
Evidence experimental; cloned [3]
Validated targets
Predicted targets

Mature sequence hsa-miR-148b-3p

Accession MIMAT0000759
Previous IDshsa-miR-148b

63 - 


 - 84

Get sequence
Deep sequencing3343 reads, 52 experiments
Evidence experimental; cloned [3-4]
Validated targets
Predicted targets


PMID:14691248 "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons" Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G Proc Natl Acad Sci U S A. 101:360-365(2004).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).