Stem-loop sequence hsa-mir-380

Accession

MI0000788

Symbol

HGNC:MIR380

Description

Homo sapiens miR-380 stem-loop

Gene family

MIPF0000126; mir-379

Stem-loop

      guu       ga       c   c 
aagaug   gaccaua  acaugcg uau u
||||||   |||||||  ||||||| |||  
uucuac   cugguau  uguaugc gug c
      -ac       aa       u   u 

Deep sequencing

15 reads, 5 experiments

Comments

Landgraf et al. confirm that the 3' product is the predominant one [3].

Genome context

• Coordinates (GRCh37.p5): chr14: 101491354-101491414 [+]
• Overlapping transcripts:

  sense

  ENST00000362112 ; MIR380-201; exon 1

  ENST00000362112 ; MIR380-201; exon 1

  antisense

  ENST00000362112 ; MIR380-201; exon 1

Clustered miRNAs

< 10kb from hsa-mir-380

• hsa-mir-379: chr14: 101488403-101488469 [+]
• hsa-mir-411: chr14: 101489662-101489757 [+]
• hsa-mir-299: chr14: 101490131-101490193 [+]
• hsa-mir-380: chr14: 101491354-101491414 [+]
• hsa-mir-1197: chr14: 101491901-101491988 [+]
• hsa-mir-323a: chr14: 101492069-101492154 [+]
• hsa-mir-758: chr14: 101492357-101492444 [+]
• hsa-mir-329-1: chr14: 101493122-101493201 [+]
• hsa-mir-329-2: chr14: 101493437-101493520 [+]
• hsa-mir-494: chr14: 101495971-101496051 [+]
• hsa-mir-1193: chr14: 101496389-101496466 [+]
• hsa-mir-543: chr14: 101498324-101498401 [+]
• hsa-mir-495: chr14: 101500092-101500173 [+]

Database links

• ENTREZGENE: 494329;MIR380
• HGNC: 31873;MIR380

Mature sequence hsa-miR-380-5p

• Accession: MIMAT0000734
• Previous IDs: hsa-miR-380-5p;hsa-miR-380*
• Sequence: 5 - ugguugaccauagaacaugcgc - 26
• Deep sequencing: 4 reads, 3 experiments
• Evidence: by similarity; MI0000797
• Predicted targets:
  • DIANA-MICROT:hsa-miR-380-5p
  • MICRORNA.ORG:hsa-miR-380-5p
  • MIRDB:hsa-miR-380-5p
  • RNA22-HSA:hsa-miR-380-5p
  • TARGETMINER:hsa-miR-380-5p

Mature sequence hsa-miR-380-3p

• Accession: MIMAT0000735
• Previous IDs: hsa-miR-380-3p;hsa-miR-380
• Sequence: 40 - uauguaauaugguccacaucuu - 61
• Deep sequencing: 11 reads, 2 experiments
• Evidence: experimental; cloned [3]
• Predicted targets:
  • DIANA-MICROT:hsa-miR-380-3p
  • MICRORNA.ORG:hsa-miR-380-3p
  • MIRDB:hsa-miR-380-3p
  • RNA22-HSA:hsa-miR-380-3p
  • TARGETMINER:hsa-miR-380-3p
  • TARGETSCAN-VERT:hsa-miR-380

References

1. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
2. PMID:15310658 "A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain" Seitz H, Royo H, Bortolin ML, Lin SP, Ferguson-Smith AC, Cavaille J Genome Res. 14:1741-1748(2004).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).