Stem-loop sequence hsa-mir-374a

Accession

MI0000782

Previous IDs

hsa-mir-374

Symbol

HGNC:MIR374A

Description

Homo sapiens miR-374a stem-loop

Gene family

MIPF0000288; mir-374

Stem-loop

     c   c            c           u 
uacau ggc auuauaauacaa cugauaagugu a
||||| ||| |||||||||||| |||||||||||  
augug cug uaauguuauguu gacuauucacg u
     u   u            a           a 

Deep sequencing

3447 reads, 36 experiments

Genome context

• Coordinates (GRCh37.p5): chrX: 73507121-73507192 [-]
• Overlapping transcripts:

  sense

  OTTHUMT00000057255 ; NCRNA00182-001; intron 1

  OTTHUMT00000057256 ; NCRNA00182-002; intron 1

  OTTHUMT00000057257 ; NCRNA00182-003; intron 1

  OTTHUMT00000057258 ; NCRNA00182-004; intron 1

  OTTHUMT00000057256 ; NCRNA00182-002; intron 1

  OTTHUMT00000057255 ; NCRNA00182-001; intron 1

  OTTHUMT00000057257 ; NCRNA00182-003; intron 1

  OTTHUMT00000057258 ; NCRNA00182-004; intron 1

  OTTHUMT00000057256 ; FTX-002; intron 1

  OTTHUMT00000057255 ; FTX-001; intron 1

  OTTHUMT00000057257 ; FTX-003; intron 1

  OTTHUMT00000057258 ; FTX-004; intron 1

  ENST00000429124 ; FTX-001; intron 1

  ENST00000430772 ; FTX-002; intron 1

  ENST00000418855 ; FTX-003; intron 1

  ENST00000455395 ; FTX-004; intron 1

  ENST00000430772 ; FTX-002; intron 1

  ENST00000429124 ; FTX-001; intron 1

  ENST00000418855 ; FTX-003; intron 1

  ENST00000455395 ; FTX-004; intron 1

  ENST00000430772 ; FTX-002; intron 1

  ENST00000429124 ; FTX-001; intron 1

  ENST00000418855 ; FTX-003; intron 1

  ENST00000455395 ; FTX-004; intron 1

Clustered miRNAs

< 10kb from hsa-mir-374a

• hsa-mir-374a: chrX: 73507121-73507192 [-]
• hsa-mir-545: chrX: 73506939-73507044 [-]

Database links

• ENTREZGENE: 442919;MIR374A
• HGNC: 31788;MIR374A

Mature sequence hsa-miR-374a-5p

• Accession: MIMAT0000727
• Previous IDs: hsa-miR-374;hsa-miR-374a
• Sequence: 12 - uuauaauacaaccugauaagug - 33
• Deep sequencing: 2083 reads, 35 experiments
• Evidence: experimental; cloned [1-4], Northern [1]
• Validated targets:
  • TARBASE:hsa-miR-374a-5p
• Predicted targets:
  • DIANA-MICROT:hsa-miR-374a-5p
  • MICRORNA.ORG:hsa-miR-374a-5p
  • MIRDB:hsa-miR-374a-5p
  • RNA22-HSA:hsa-miR-374a-5p
  • TARGETMINER:hsa-miR-374a-5p
  • TARGETSCAN-VERT:hsa-miR-374a
  • PICTAR-VERT:hsa-miR-374

Mature sequence hsa-miR-374a-3p

• Accession: MIMAT0004688
• Previous IDs: hsa-miR-374a*
• Sequence: 42 - cuuaucagauuguauuguaauu - 63
• Deep sequencing: 1363 reads, 16 experiments
• Evidence: experimental; cloned [3]
• Predicted targets:
  • DIANA-MICROT:hsa-miR-374a-3p
  • MICRORNA.ORG:hsa-miR-374a-3p
  • MIRDB:hsa-miR-374a-3p
  • RNA22-HSA:hsa-miR-374a-3p
  • TARGETMINER:hsa-miR-374a-3p
  • PICTAR-VERT:hsa-miR-374

References

1. PMID:15183728 "Human embryonic stem cells express a unique set of microRNAs" Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS Dev Biol. 270:488-498(2004).
2. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).