Stem-loop sequence mmu-mir-9-1

AccessionMI0000720
Symbol MGI:Mir9-1
DescriptionMus musculus miR-9-1 stem-loop
Gene family MIPF0000014; mir-9
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-9/mir-79_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-9 microRNA (homologous to miR-79), is a short non-coding RNA gene involved in gene regulation. The mature ~21nt miRNAs are processed from hairpin precursor sequences by the Dicer enzyme. The dominant mature miRNA sequence is processed from the 5' arm of the mir-9 precursor, and from the 3' arm of the mir-79 precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In vertebrates, miR-9 is highly expressed in the brain, and is suggested to regulate neuronal differentiation. A number of specific targets of miR-9 have been proposed, including the transcription factor REST and its partner CoREST.

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Stem-loop
   c       guug   uc               g      u  ug 
5'  gggguug    uua  uuugguuaucuagcu uaugag gg  u
    |||||||    |||  ||||||||||||||| |||||| ||  g
3'  ccccaau    aau  aagccaauagaucga auacuu cu  g
   a       -aaa   ga               a      -  ga 
Get sequence
Deep sequencing
3784435 reads, 1.68e+04 reads per million, 104 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Genome context
Coordinates (GRCm38) Overlapping transcripts
chr3: 88215598-88215686 [+]
sense
OTTMUST00000112727 ; RP23-168E14.7-003; intron 1
OTTMUST00000112771 ; RP23-168E14.7-011; intron 1
OTTMUST00000112728 ; RP23-168E14.7-004; intron 1
OTTMUST00000112725 ; RP23-168E14.7-001; intron 2
OTTMUST00000112726 ; RP23-168E14.7-002; intron 2
ENSMUST00000181396 ; Gm3764-004; intron 1
ENSMUST00000181356 ; Gm3764-011; intron 1
ENSMUST00000181636 ; Gm3764-003; intron 1
ENSMUST00000180582 ; Gm3764-002; intron 2
ENSMUST00000181550 ; Gm3764-001; intron 2
antisense
ENSMUST00000175135 ; Gm25641-201; exon 1
Clustered miRNAs
< 10kb from mmu-mir-9-1
mmu-mir-3093chr3: 88215171-88215257 [+]
mmu-mir-9-1chr3: 88215598-88215686 [+]
Database links

Mature sequence mmu-miR-9-5p

Accession MIMAT0000142
Previous IDsmmu-miR-9
Sequence

16 - 

ucuuugguuaucuagcuguauga

 - 38

Get sequence
Deep sequencing3602885 reads, 87 experiments
Evidence experimental; cloned [1-2,4], Illumina [5-6]
Validated targets
Predicted targets

Mature sequence mmu-miR-9-3p

Accession MIMAT0000143
Previous IDsmmu-miR-9*
Sequence

55 - 

auaaagcuagauaaccgaaagu

 - 76

Get sequence
Deep sequencing336898 reads, 66 experiments
Evidence experimental; cloned [1,4], Illumina [5-6]
Predicted targets

References

1
PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2
PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
3
4
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5
PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
6
PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).