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miRBase |
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Stem-loop sequence mmu-mir-124-1 |
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Accession | MI0000716 (change log) | |||||
Previous IDs | mmu-mir-124a-1 | |||||
Symbol | MGI:Mir124a-1 | |||||
Description | Mus musculus miR-124-1 stem-loop | |||||
Gene family | MIPF0000021; mir-124 | |||||
Community annotation |
This text is a summary paragraph taken from the Wikipedia entry entitled mir-124_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ... The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373), nematode worms (MI0000302), mouse (MI0000150) and human (MI0000443). The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3' arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation. However these results are controversial since other reports have described a role for miR-124 during neuronal differentiation. |
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Stem-loop |
a uc cc a ga uaaau 5' ggccuc ucu guguucac gcg ccuugauu g |||||| ||| |||||||| ||| |||||||| u 3' ucgggg aga cguaagug cgc ggaauuaa c g ua ac g ac cauac |
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Deep sequencing |
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Confidence |
Annotation confidence: high
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Comments |
miR-124 was cloned from mouse brain [1] and embryonic stem cells [2] by independent groups. There are 3 predicted precursor hairpin sequences: mir-124-1 (MI0000716) on chromosome 14, mir-124-2 (MI0000717) on chromosome 3, and mir-124-3 (previously known as miR-124 here, MI0000150) on chromosome 2. All have closely related predicted human homologues (MI0000443, MI0000444 and MI0000445). Lagos-Quintana et al. also report a mature miRNA sequence miR-124b, with a G insertion at position 12 [1]. miR-124b is not found in either the mouse or human genome assemblies. |
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Genome context |
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Clustered miRNAs |
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Database links |
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Mature sequence mmu-miR-124-5p |
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Accession | MIMAT0004527 |
Previous IDs | mmu-miR-124* |
Sequence |
14 - cguguucacagcggaccuugau - 35 |
Deep sequencing | 5935 reads, 24 experiments |
Evidence | experimental; cloned [4], Illumina [5-6] |
Database links |
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Predicted targets |
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Mature sequence mmu-miR-124-3p |
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Accession | MIMAT0000134 |
Previous IDs | mmu-miR-124a;mmu-miR-124 |
Sequence |
53 - uaaggcacgcggugaaugcc - 72 |
Deep sequencing | 2622251 reads, 54 experiments |
Evidence | experimental; cloned [1-4], Illumina [5-6] |
Database links |
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Predicted targets |
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References |
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1 |
PMID:12007417
"Identification of tissue-specific microRNAs from mouse"
Curr Biol. 12:735-739(2002).
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2 |
PMID:12919684
"Embryonic stem cell-specific MicroRNAs"
Dev Cell. 5:351-358(2003).
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3 |
PMID:15538371
"A pancreatic islet-specific microRNA regulates insulin secretion"
Nature. 432:226-230(2004).
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4 |
PMID:17604727
"A mammalian microRNA expression atlas based on small RNA library sequencing"
Cell. 129:1401-1414(2007).
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5 |
PMID:20215419
"MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing"
Mol Hum Reprod. 16:463-471(2010).
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6 |
PMID:20413612
"Mammalian microRNAs: experimental evaluation of novel and previously annotated genes"
Genes Dev. 24:992-1009(2010).
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