Stem-loop sequence mmu-mir-351

Accession

MI0000643

Symbol

MGI:Mir351

Description

Mus musculus miR-351 stem-loop

Gene family

MIPF0000244; mir-351

Stem-loop

----ca      ----     u     ug   a   c     g    gagugaa 
      uggcac    cuccg uuccc  agg gcc uuuga ccug       a
      ||||||    ||||| |||||  ||| ||| ||||| ||||        
      auugug    gaggu aaggg  ucc cgg gaacu ggac       a
cuucaa      agaa     c     --   g   a     -    aaaaaaa 

Deep sequencing

42560 reads, 97 experiments

Comments

The predominant miRNA cloned by Langraf et al. has a 3' terminal U residue, which is incompatible with the genome sequence [1].

Genome context

• Coordinates (GRCm38): chrX: 53053255-53053353 [-]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from mmu-mir-351

• mmu-mir-322: chrX: 53054255-53054349 [-]
• mmu-mir-503: chrX: 53053984-53054054 [-]
• mmu-mir-351: chrX: 53053255-53053353 [-]
• mmu-mir-542: chrX: 53049403-53049487 [-]
• mmu-mir-450a-2: chrX: 53048299-53048367 [-]
• mmu-mir-450a-1: chrX: 53048154-53048244 [-]
• mmu-mir-450b: chrX: 53047997-53048078 [-]

Database links

• ENTREZGENE: 723910;Mir351
• MGI: 3619367;Mir351

Mature sequence mmu-miR-351-5p

• Accession: MIMAT0000609
• Previous IDs: mmu-miR-351
• Sequence: 16 - ucccugaggagcccuuugagccug - 39
• Deep sequencing: 37343 reads, 81 experiments
• Evidence: experimental; cloned [1], Solexa [2,4]
• Validated targets:
  • TARBASE:mmu-miR-351-5p
• Predicted targets:
  • DIANA-MICROT:mmu-miR-351-5p
  • MICRORNA.ORG:mmu-miR-351-5p
  • MIRDB:mmu-miR-351-5p
  • RNA22-MMU:mmu-miR-351-5p
  • TARGETSCAN-VERT:mmu-miR-351

Mature sequence mmu-miR-351-3p

• Accession: MIMAT0017042
• Previous IDs: mmu-miR-351*
• Sequence: 58 - ggucaagaggcgccugggaac - 78
• Deep sequencing: 4409 reads, 73 experiments
• Evidence: experimental; 454 [3], Solexa [4]
• Predicted targets:
  • DIANA-MICROT:mmu-miR-351-3p
  • MIRDB:mmu-miR-351-3p
  • RNA22-MMU:mmu-miR-351-3p

References

1. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
2. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
3. PMID:20668074 "Identification and analysis of expression of novel microRNAs of murine gammaherpesvirus 68" Zhu JY, Strehle M, Frohn A, Kremmer E, Hofig KP, Meister G, Adler H J Virol. 84:10266-10275(2010).
4. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).