Stem-loop sequence mmu-mir-24-2

AccessionMI0000572 (change log)
Symbol MGI:Mir24-2
DescriptionMus musculus miR-24-2 stem-loop
Gene family MIPF0000041; mir-24
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-24_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-24 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 is conserved in various species, and is clustered with miR-23 and miR-27, on human chromosome 9 and 19. Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic differentiation and also to promote keratinocyte differentiation by repressing actin-cytoskeleton regulators PAK4, Tsk5 and ArhGAP19.

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   -   ucu    ----     ccgc    c  g   a         aa    ug  u 
5'  gcc   cucc    gggcu    cucc gu ccu cugagcuga  cagu  au c
    |||   ||||    |||||    |||| || ||| |||||||||  ||||  ||  
3'  cgg   gagg    cccga    gagg ca gga gacuugacu  guca  ug c
   a   -uc    aucc     -ccu    a  a   c         cg    cg  a 
Get sequence
Deep sequencing
1146098 reads, 1.1e+04 reads per million, 76 experiments
Confidence Annotation confidence: high
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Genome context
Coordinates (GRCm38; GCA_000001635.2) Overlapping transcripts
chr8: 84208815-84208921 [+]
OTTMUST00000112758 ; RP24-64D24.4-001; exon 1
ENSMUST00000180630 ; Gm26532-001; exon 1
Clustered miRNAs
< 10kb from mmu-mir-24-2
mmu-mir-23achr8: 84208518-84208592 [+]
mmu-mir-27achr8: 84208672-84208758 [+]
mmu-mir-24-2chr8: 84208815-84208921 [+]
mmu-mir-3074-2chr8: 84208825-84208907 [-]
Database links

Mature sequence mmu-miR-24-2-5p

Accession MIMAT0005440
Previous IDsmmu-miR-24-2*

25 - 


 - 46

Get sequence
Deep sequencing26243 reads, 76 experiments
Evidence experimental; cloned [6], Illumina [7-8]
Database links
Predicted targets

Mature sequence mmu-miR-24-3p

Accession MIMAT0000219
Previous IDsmmu-miR-24

61 - 


 - 82

Get sequence
Deep sequencing2239408 reads, 76 experiments
Evidence experimental; cloned [1-2,4-6], Northern [2], Illumina [7]
Database links
Predicted targets


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PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).