Stem-loop sequence mmu-mir-208a
|Description||Mus musculus miR-208a stem-loop|
|Gene family||MIPF0000178; mir-208|
miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. In humans, the gene for miR-208 is located in an intron of MYH7.
miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
miR-208 has been deemed a "myomiR" as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133. miR-208 is though to be dysregulated in various cardiovascular diseases.
miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development. It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.
A preliminary study has shown a potential use in the prognosis of dilated cardiomyopathy. Another application has been suggested as using plasma concentration of miR-208 as a biomarker of damaged cardiac muscle cells.
 Further reading
u g ug g c gg c a uccuuugac gg agcuuuu gc cg uuauac ug c ||||||||| || ||||||| || || |||||| || a aggagacug uu ucgaaaa cg gc aauaug ac c g g gu a a ag c u
Mature sequence mmu-miR-208a-5p
|Deep sequencing||215 reads, 17 experiments|
|Evidence||experimental; Solexa |
Mature sequence mmu-miR-208a-3p
|Deep sequencing||404 reads, 22 experiments|
|Evidence||experimental; cloned [1-2], Solexa |
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Cell. 129:1401-1414(2007).
PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Genes Dev. 24:992-1009(2010).