Stem-loop sequence hsa-mir-150

AccessionMI0000479 (change log)
Symbol HGNC:MIR150
DescriptionHomo sapiens miR-150 stem-loop
Gene family MIPF0000197; mir-150
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled MiR-150. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes. It is also thought to control B and T cell differentiation, alongside mir-155.

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Stem-loop
   c      u  -            ac   u       u -   g 
5'  ucccca gg cccugucuccca  ccu guaccag g cug g
    |||||| || ||||||||||||  ||| ||||||| | |||  
3'  aggggu cc gggacagggggu  gga caugguc c gac c
   c      -  a            cc   -       c a   u 
Get sequence
Deep sequencing
60352 reads, 1.56e+03 reads per million, 55 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chr19: 49500785-49500868 [-]
antisense
OTTHUMT00000466235 ; RUVBL2-001; intron 1
OTTHUMT00000466236 ; RUVBL2-002; intron 1
OTTHUMT00000466237 ; RUVBL2-007; intron 1
OTTHUMT00000466239 ; RUVBL2-003; intron 1
OTTHUMT00000466241 ; RUVBL2-005; intron 1
OTTHUMT00000466242 ; RUVBL2-006; intron 1
OTTHUMT00000466243 ; RUVBL2-008; intron 1
OTTHUMT00000466240 ; RUVBL2-011; intron 2
OTTHUMT00000466238 ; RUVBL2-010; intron 3
ENST00000595090 ; RUVBL2-001; intron 1
ENST00000601968 ; RUVBL2-002; intron 1
ENST00000596837 ; RUVBL2-007; intron 1
ENST00000594017 ; RUVBL2-003; intron 1
ENST00000596247 ; RUVBL2-005; intron 1
ENST00000221413 ; RUVBL2-006; intron 1
ENST00000593570 ; RUVBL2-008; intron 1
ENST00000413176 ; RUVBL2-201; intron 1
ENST00000598768 ; RUVBL2-011; intron 2
ENST00000595811 ; RUVBL2-010; intron 3
Database links

Mature sequence hsa-miR-150-5p

Accession MIMAT0000451
Previous IDshsa-miR-150
Sequence

16 - 

ucucccaacccuuguaccagug

 - 37

Get sequence
Deep sequencing55253 reads, 55 experiments
Evidence experimental; cloned [2]
Database links
Predicted targets

Mature sequence hsa-miR-150-3p

Accession MIMAT0004610
Previous IDshsa-miR-150*
Sequence

51 - 

cugguacaggccugggggacag

 - 72

Get sequence
Deep sequencing5099 reads, 34 experiments
Evidence experimental; cloned [2]
Database links
Predicted targets

References

1
PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).