Stem-loop sequence hsa-mir-134
|Description||Homo sapiens miR-134 stem-loop|
|Gene family||MIPF0000112; mir-134|
miR-134 is a family of microRNA precursors found in mammals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-134 precursor is the microRNA mir-134. miR-134 was one of a number of microRNAs found to be increasingly expressed in schizophrenia.
miR-134 is a family of microRNA precursors found in mammals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, mature product, of the miR-134 precursor is the microRNA mir-134.
miR-134 is a brain-specific microRNA; in rats it is localised specifically in hippocampal neurons and may indirectly regulate synaptic development through antisense pairing with LIMK1 mRNA. In the human brain, SIRT1 is thought to mediate CREB protein through miR-134, giving the microRNA a role in higher brain functions such a memory formation.
c gu u -a g --- g agggu gugacugg ug cca aggg gcau c ||||| |||||||| || ||| |||| |||| a uccca cacugauc ac ggu uccc ugug c c ac c cg g acu u
miR-134 was first identified by cloning studies in mouse . Its expression was later verified in human embryonic stem cells . The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
Mature sequence hsa-miR-134
|Deep sequencing||1579 reads, 15 experiments|
|Evidence||experimental; cloned [2-4]|
PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Curr Biol. 12:735-739(2002).
PMID:15183728 "Human embryonic stem cells express a unique set of microRNAs" Dev Biol. 270:488-498(2004).
PMID:15891114 "Clustering and conservation patterns of human microRNAs" Nucleic Acids Res. 33:2697-2706(2005).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Cell. 129:1401-1414(2007).