Stem-loop sequence hsa-mir-125a

Accession

MI0000469

Symbol

HGNC:MIR125A

Description

Homo sapiens miR-125a stem-loop

Gene family

MIPF0000017; mir-125

Stem-loop

u     u u     uc  ug   c    ua        ----  a 
 gccag c cuagg  cc  aga ccuu  accuguga    gg c
 ||||| | |||||  ||  ||| ||||  ||||||||    ||  
 cgguc g ggucc  gg  ucu ggag  uggacacu    cc a
c     u c     ga  gu   u    --        ggga  u 

Deep sequencing

4357 reads, 48 experiments

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

• Coordinates (GRCh37.p5): chr19: 52196507-52196592 [+]
• Overlapping transcripts:

  antisense

  ENST00000503177 ; AC018755.2-201; exon 1

Clustered miRNAs

< 10kb from hsa-mir-125a

• hsa-mir-99b: chr19: 52195865-52195934 [+]
• hsa-let-7e: chr19: 52196039-52196117 [+]
• hsa-mir-125a: chr19: 52196507-52196592 [+]

Database links

• ENTREZGENE: 406910;MIR125A
• HGNC: 31505;MIR125A

Mature sequence hsa-miR-125a-5p

• Accession: MIMAT0000443
• Previous IDs: hsa-miR-125a
• Sequence: 15 - ucccugagacccuuuaaccuguga - 38
• Deep sequencing: 4276 reads, 48 experiments
• Evidence: experimental; cloned [2-3]
• Validated targets:
  • MIRECORDS:hsa-miR-125a-5p
  • MIRTARBASE:hsa-miR-125a-5p
  • TARBASE:hsa-miR-125a-5p
• Predicted targets:
  • DIANA-MICROT:hsa-miR-125a-5p
  • MICRORNA.ORG:hsa-miR-125a-5p
  • MIRDB:hsa-miR-125a-5p
  • RNA22-HSA:hsa-miR-125a-5p
  • TARGETMINER:hsa-miR-125a-5p
  • TARGETSCAN-VERT:hsa-miR-125a-5p
  • PICTAR-VERT:hsa-miR-125a

Mature sequence hsa-miR-125a-3p

• Accession: MIMAT0004602
• Sequence: 53 - acaggugagguucuugggagcc - 74
• Deep sequencing: 81 reads, 11 experiments
• Evidence: experimental; cloned [2-3]
• Predicted targets:
  • DIANA-MICROT:hsa-miR-125a-3p
  • MICRORNA.ORG:hsa-miR-125a-3p
  • MIRDB:hsa-miR-125a-3p
  • RNA22-HSA:hsa-miR-125a-3p
  • TARGETMINER:hsa-miR-125a-3p
  • TARGETSCAN-VERT:hsa-miR-125a-3p
  • PICTAR-VERT:hsa-miR-125a

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).