Stem-loop sequence hsa-mir-191

Symbol HGNC:MIR191
DescriptionHomo sapiens miR-191 stem-loop
Gene family MIPF0000194; mir-191
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled miR-191. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-191 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference. miR-191 has been found to be dysregulated in a large number of different types of human tumour, including those of colorectal, breast and prostate cancers. Despite these cancer links, target genes of the mature miRNA have not been characterised, and it is not known which factors lead to its dysregulation in certain tumour cells. The expression profile of miR-191 could be implemented in prognosis of acute myeloid leukaemia, with higher than average levels of miR-191 suggesting a lower survival probability.

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   c   u   c      ca         c  aa       uu  -  c 
5'  ggc gga agcggg  acggaaucc aa  gcagcug  gu cu c
    ||| ||| ||||||  ||||||||| ||  |||||||  || ||  
3'  ccg ccu ucgucc  ugcuuuagg uu  cgucgac  ua ga a
   u   u   c      cc         -  cg       cu  c  g 
Get sequence
Deep sequencing
124391 reads, 1.24e+04 reads per million, 81 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. The expression of this miRNA was later confirmed in human HL-60 leukemia cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
Coordinates (GRCh38) Overlapping transcripts
chr3: 49020618-49020709 [-]
OTTHUMT00000345432 ; RP13-131K19.1-001; intron 1
OTTHUMT00000345433 ; RP13-131K19.1-002; intron 1
ENST00000415982 ; RP13-131K19.1-001; intron 1
ENST00000429681 ; RP13-131K19.1-002; intron 1
OTTHUMT00000345437 ; ARIH2-034; exon 2
OTTHUMT00000345252 ; ARIH2-006; exon 15
OTTHUMT00000257525 ; ARIH2-001; exon 16
OTTHUMT00000345248 ; ARIH2-002; exon 17
ENST00000487891 ; ARIH2-034; exon 2
ENST00000452385 ; ARIH2-006; exon 15
ENST00000356401 ; ARIH2-001; exon 16
ENST00000449376 ; ARIH2-002; exon 17
Clustered miRNAs
< 10kb from hsa-mir-191
hsa-mir-191chr3: 49020618-49020709 [-]
hsa-mir-425chr3: 49020148-49020234 [-]
Database links

Mature sequence hsa-miR-191-5p

Accession MIMAT0000440
Previous IDshsa-miR-191

16 - 


 - 38

Get sequence
Deep sequencing17314 reads, 77 experiments
Evidence experimental; cloned [2-5]
Validated targets
Predicted targets

Mature sequence hsa-miR-191-3p

Accession MIMAT0001618
Previous IDshsa-miR-191*

58 - 


 - 79

Get sequence
Deep sequencing186 reads, 31 experiments
Evidence experimental; cloned [2-4]
Predicted targets


PMID:12554859 "New microRNAs from mouse and human" Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T RNA. 9:175-179(2003).
PMID:15325244 "Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells" Kasashima K, Nakamura Y, Kozu T Biochem Biophys Res Commun. 322:403-410(2004).
PMID:15891114 "Clustering and conservation patterns of human microRNAs" Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H Nucleic Acids Res. 33:2697-2706(2005).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).