Stem-loop sequence hsa-mir-132

AccessionMI0000449
Symbol HGNC:MIR132
DescriptionHomo sapiens miR-132 stem-loop
Gene family MIPF0000065; mir-132
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-132. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology miR-132 microRNA is a short non-coding RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, generally reducing protein levels through the cleavage of mRNAs or the repression of their translation. Several targets for miR-132 have been described, including mediators of neurological development, synaptic transmission, inflammation and angiogenesis.

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Stem-loop
   c   cccc    -  c a    a         uuc          --gu g 
5'  cgc    gcgu cu c gggc accguggcu   gauuguuacu    g g
    |||    |||| || | |||| |||||||||   ||||||||||    |  
3'  gcg    cgca ga g cccg ugguaccga   cugacaaugg    c a
   c   cacc    c  c c    c         cau          aggu a 
Get sequence
Deep sequencing
6975 reads, 616 reads per million, 66 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context
Coordinates (GRCh38) Overlapping transcripts
chr17: 2049908-2050008 [-]
sense
OTTHUMT00000438476 ; SMG6-011; intron 1
OTTHUMT00000438474 ; SMG6-010; intron 2
OTTHUMT00000438059 ; SMG6-005; intron 5
OTTHUMT00000438057 ; SMG6-002; intron 6
OTTHUMT00000437826 ; SMG6-001; intron 13
ENST00000570874 ; SMG6-011; intron 1
ENST00000575454 ; SMG6-010; intron 2
ENST00000536871 ; SMG6-005; intron 5
ENST00000354901 ; SMG6-002; intron 6
ENST00000263073 ; SMG6-001; intron 13
ENST00000544865 ; SMG6-201; intron 13
Clustered miRNAs
< 10kb from hsa-mir-132
hsa-mir-212chr17: 2050271-2050380 [-]
hsa-mir-132chr17: 2049908-2050008 [-]
Database links

Mature sequence hsa-miR-132-5p

Accession MIMAT0004594
Previous IDshsa-miR-132*
Sequence

23 - 

accguggcuuucgauuguuacu

 - 44

Get sequence
Deep sequencing238 reads, 39 experiments
Evidence experimental; cloned [2]
Predicted targets

Mature sequence hsa-miR-132-3p

Accession MIMAT0000426
Previous IDshsa-miR-132
Sequence

59 - 

uaacagucuacagccauggucg

 - 80

Get sequence
Deep sequencing371 reads, 46 experiments
Evidence experimental; cloned [2-3]
Validated targets
Predicted targets

References

1
PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).