Stem-loop sequence hsa-mir-122

AccessionMI0000442 (change log)
Previous IDshsa-mir-122a
Symbol HGNC:MIR122
DescriptionHomo sapiens miR-122 stem-loop
Gene family MIPF0000095; mir-122
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled MiR-122. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-122 is a miRNA that is conserved between vertebrate species. miR-122 is not present in invertebrates, and no close paralogs of miR-122 have been detected. miR-122 expression is specific to the liver, where it has been implicated as a regulator of fatty-acid metabolism in mouse studies. Reduced miR-122 levels are associated with hepatocellular carcinoma. miR-122 also plays an important positive role in the regulation of hepatitis C virus replication.

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   c        -      gg       c           --u  c 
5'  cuuagcag agcugu  aguguga aaugguguuug   gu u
    |||||||| ||||||  ||||||| |||||||||||   ||  
3'  ggaucguc ucgaua  ucacacu uuaccgcaaac   ca a
   c        a      aa       a           uau  a 
Get sequence
Deep sequencing
377180 reads, 2.09e+03 reads per million, 58 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chr18: 58451074-58451158 [+]
OTTHUMT00000449086 ; RP11-325K19.1-001; intron 3
ENST00000591869 ; RP11-325K19.1-001; intron 3
Clustered miRNAs
< 10kb from hsa-mir-122
hsa-mir-122chr18: 58451074-58451158 [+]
hsa-mir-122bchr18: 58451080-58451152 [-]
Database links

Mature sequence hsa-miR-122-5p

Accession MIMAT0000421
Previous IDshsa-miR-122a;hsa-miR-122

15 - 


 - 36

Get sequence
Deep sequencing358386 reads, 57 experiments
Evidence experimental; cloned [2-3], Northern [2]
Database links
Predicted targets

Mature sequence hsa-miR-122-3p

Accession MIMAT0004590
Previous IDshsa-miR-122*

51 - 


 - 72

Get sequence
Deep sequencing18778 reads, 14 experiments
Evidence experimental; cloned [3]
Predicted targets


PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
PMID:15978578 "Identification of human fetal liver miRNAs by a novel method" Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X FEBS Lett. 579:3849-3854(2005).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).