Stem-loop sequence hsa-mir-223

AccessionMI0000300
Symbol HGNC:MIR223
DescriptionHomo sapiens miR-223 stem-loop
Gene family MIPF0000067; mir-223
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-223. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology MicroRNA-223 (miR-223) is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-223 is a hematopoietic specific microRNA with crucial functions in myeloid lineage development. It plays an essential role in promoting granulocytic differentiation while also being associated with the suppression of erythrocytic differentiation. miR-223 is commonly repressed in hepatocellular carcinoma and leukemia. Higher expression levels of miRNA-223 are associated with extranodal marginal-zone lymphoma of mucosa-associated lymphoid tissue of the stomach and recurrent ovarian cancer. In some cancers the microRNA-223 down-regulation is correlated with higher tumor burden, disease aggressiveness, and poor prognostic factors. MicroRNA-223 is also associated with rheumatoid arthritis, sepsis, type 2 diabetes, and hepatic ischemia.

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Stem-loop
   c    ccuccu   -     a    cc u              gaguug       cau 
5'  cugg      gca gugcc cgcu  g guauuugacaagcu      gacacuc   g
    ||||      ||| ||||| ||||  | ||||||||||||||      |||||||   u
3'  gacc      cgu cacgg guga  c cauaaacuguuuga      cugugag   g
   -    ---auu   a     c    ac c              ------       aug 
Get sequence
Deep sequencing
16928 reads, 5.81e+03 reads per million, 60 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
Coordinates (GRCh38) Overlapping transcripts
chrX: 66018870-66018979 [+]
intergenic
Database links

Mature sequence hsa-miR-223-5p

Accession MIMAT0004570
Previous IDshsa-miR-223*
Sequence

26 - 

cguguauuugacaagcugaguu

 - 47

Get sequence
Deep sequencing1531 reads, 16 experiments
Evidence experimental; cloned [2]
Predicted targets

Mature sequence hsa-miR-223-3p

Accession MIMAT0000280
Previous IDshsa-miR-223
Sequence

68 - 

ugucaguuugucaaauacccca

 - 89

Get sequence
Deep sequencing3043 reads, 54 experiments
Evidence experimental; cloned [2]
Validated targets
Predicted targets

References

1
PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).