Stem-loop sequence hsa-mir-221

AccessionMI0000298 (change log)
Symbol HGNC:MIR221
DescriptionHomo sapiens miR-221 stem-loop
Gene family MIPF0000051; mir-221
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-221_microRNA. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology mir-221 microRNA (and its paralogue, mir-222) is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-221 is an oncogenic microRNA. It targets CD117, which then prevents cell migration and proliferation in endothelial cells. miR-221 is known as an anti angiogenic miRNA. Recent important studies have reported that miR-221 is also involved in induction of angiogenesis. RNA induced Silencing Complex (RISC) proteins SND1 and AEG-1 induces miR-221 expression in Liver cancer. In liver cancer miR-221 induces the tumor angiogenesis.

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     |||||    |||||||    ||| |||| ||  ||| |||||||||    |||| ||| u
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   cu     acaa       ----   g    u  gu   c         ----    a   a 
Get sequence
Deep sequencing
1279737 reads, 6.58e+03 reads per million, 77 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and later validated in human HL-60 leukemia cells [2].

Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chrX: 45746157-45746266 [-]
Clustered miRNAs
< 10kb from hsa-mir-221
hsa-mir-222chrX: 45747015-45747124 [-]
hsa-mir-221chrX: 45746157-45746266 [-]
Database links

Mature sequence hsa-miR-221-5p

Accession MIMAT0004568
Previous IDshsa-miR-221*

25 - 


 - 46

Get sequence
Deep sequencing93385 reads, 69 experiments
Evidence experimental; cloned [3]
Database links
Predicted targets

Mature sequence hsa-miR-221-3p

Accession MIMAT0000278
Previous IDshsa-miR-221

65 - 


 - 87

Get sequence
Deep sequencing1186299 reads, 77 experiments
Evidence experimental; cloned [2-4], Illumina [5]
Database links
Predicted targets


PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
PMID:15325244 "Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells" Kasashima K, Nakamura Y, Kozu T Biochem Biophys Res Commun. 322:403-410(2004).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).