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Stem-loop sequence MI0000295

Accession MI0000295
ID hsa-mir-218-2
Symbol HGNC:MIR218-2
Description Homo sapiens miR-218-2 stem-loop
Stem-loop 
gac   --uc  u    g       uuu         cu        gguggaacga  g 
   cag    gc gcgg gcuuucc   gugcuugau  aaccaugu          ug a
   |||    || |||| |||||||   |||||||||  ||||||||          ||  
   guc    cg ugcc cgaaagg   cacgaacug  uugguaca          gc a
-ac   cucu  -    a       cgc         uc        --------ag  a
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Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2].

Genome context
Coordinates (GRCh37) Overlapping transcripts
5: 168195151-168195260 [-]
sense
OTTHUMT00000252792 ; SLIT3-001; intron 14
ENST00000442632 ; SLIT3-202; intron 10
ENST00000453547 ; SLIT3-203; intron 10
ENST00000404867 ; SLIT3-201; intron 10
ENST00000332966 ; SLIT3-001; intron 14

View flanking features
Database links
Gene family

MIPF0000026; mir-218

Mature sequence MIMAT0000275

Accession MIMAT0000275
ID hsa-miR-218
Sequence

25 -  

uugugcuugaucuaaccaugu

 - 45

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Evidence experimental; cloned [2-3]
Predicted targets

Minor miR* sequence MIMAT0004566

Accession MIMAT0004566
ID hsa-miR-218-2*
Sequence

67 -  

caugguucugucaagcaccgcg

 - 88

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Evidence experimental; cloned [2]
Predicted targets

References

1
"Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2
"A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3
"Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).