Stem-loop sequence hsa-mir-210

AccessionMI0000286
Symbol HGNC:MIR210
DescriptionHomo sapiens miR-210 stem-loop
Gene family MIPF0000086; mir-210
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-210_microRNA. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology mir-210 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-210 has been strongly linked with the hypoxia pathway, and is upregulated in response to Hypoxia-inducible factors. It is also overexpressed in cells affected by cardiac disease and tumours. MiRNA-210 in particular, has been studied for its effects in rescuing cardiac function after myocardial infarcts via the up-regulation of angiogenesis and inhibition of cardiomyocyte apoptosis.

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Stem-loop
   accc  ca    -c           gg     c   cc   -      c  c -     
5'     gg  gugc  uccaggcgcag  cagcc cug  cac cgcaca ug g cugc 
       ||  ||||  |||||||||||  ||||| |||  ||| |||||| || | ||| c
3'     cc  cgcg  ggguccguguc  gucgg gac  gug gcgugu ac c gacc 
   ---c  ag    ac           ua     c   -a   u      c  c a     
Get sequence
Deep sequencing
3296 reads, 2.05e+03 reads per million, 70 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Its expression was later verified in human BC-1 cells [2].

Genome context
Coordinates (GRCh38) Overlapping transcripts
chr11: 568089-568198 [-]
sense
OTTHUMT00000383231 ; MIR210HG-001; intron 1
OTTHUMT00000383232 ; MIR210HG-002; intron 1
OTTHUMT00000383233 ; MIR210HG-003; intron 1
OTTHUMT00000383234 ; MIR210HG-004; intron 1
ENST00000500447 ; MIR210HG-001; intron 1
ENST00000528245 ; MIR210HG-002; intron 1
ENST00000533920 ; MIR210HG-003; intron 1
ENST00000534540 ; MIR210HG-004; intron 1
Database links

Mature sequence hsa-miR-210-5p

Accession MIMAT0026475
Sequence

28 - 

agccccugcccaccgcacacug

 - 49

Get sequence
Deep sequencing54 reads, 14 experiments
Evidence experimental; Illumina [5]
Predicted targets

Mature sequence hsa-miR-210-3p

Accession MIMAT0000267
Sequence

66 - 

cugugcgugugacagcggcuga

 - 87

Get sequence
Deep sequencing1529 reads, 59 experiments
Evidence experimental; cloned [2-4], Illumina [5]
Validated targets
Predicted targets

References

1
PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2
PMID:15800047 "Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells" Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR Proc Natl Acad Sci U S A. 102:5570-5575(2005).
3
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).
5
PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).