Stem-loop sequence hsa-mir-210

Symbol HGNC:MIR210
DescriptionHomo sapiens miR-210 stem-loop
Gene family MIPF0000086; mir-210
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-210_microRNA. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology mir-210 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-210 has been strongly linked with the hypoxia pathway, and is upregulated in response to Hypoxia-inducible factors. It is also overexpressed in cells affected by cardiac disease and tumours. MiRNA-210 in particular, has been studied for its effects in rescuing cardiac function after myocardial infarcts via the up-regulation of angiogenesis and inhibition of cardiomyocyte apoptosis.

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   accc  ca    -c           gg     c   cc   -      c  c -     
5'     gg  gugc  uccaggcgcag  cagcc cug  cac cgcaca ug g cugc 
       ||  ||||  |||||||||||  ||||| |||  ||| |||||| || | ||| c
3'     cc  cgcg  ggguccguguc  gucgg gac  gug gcgugu ac c gacc 
   ---c  ag    ac           ua     c   -a   u      c  c a     
Get sequence
Deep sequencing
3296 reads, 2.05e+03 reads per million, 70 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Its expression was later verified in human BC-1 cells [2].

Genome context
Coordinates (GRCh38) Overlapping transcripts
chr11: 568089-568198 [-]
OTTHUMT00000383231 ; MIR210HG-001; intron 1
OTTHUMT00000383232 ; MIR210HG-002; intron 1
OTTHUMT00000383233 ; MIR210HG-003; intron 1
OTTHUMT00000383234 ; MIR210HG-004; intron 1
ENST00000500447 ; MIR210HG-001; intron 1
ENST00000528245 ; MIR210HG-002; intron 1
ENST00000533920 ; MIR210HG-003; intron 1
ENST00000534540 ; MIR210HG-004; intron 1
Database links

Mature sequence hsa-miR-210-5p

Accession MIMAT0026475

28 - 


 - 49

Get sequence
Deep sequencing54 reads, 14 experiments
Evidence experimental; Illumina [5]
Predicted targets

Mature sequence hsa-miR-210-3p

Accession MIMAT0000267

66 - 


 - 87

Get sequence
Deep sequencing1529 reads, 59 experiments
Evidence experimental; cloned [2-4], Illumina [5]
Validated targets
Predicted targets


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PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).
PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).