Stem-loop sequence hsa-mir-203a

AccessionMI0000283
Previous IDshsa-mir-203
Symbol HGNC:MIR203
DescriptionHomo sapiens miR-203a stem-loop
Gene family MIPF0000108; mir-203
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled MiR-203. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology miR-203 is a short non-coding RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, such as translational repression and Argonaute-catalyzed messenger RNA cleavage. miR-203 has been identified as a skin-specific microRNA, and it forms an expression gradient that defines the boundary between proliferative epidermal basal progenitors and terminally differentiating suprabasal cells. It has also been found upregulated in psoriasis and differentially expressed in some types of cancer.

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Stem-loop
   g     gg a u   g         c         u    g    a     - ug 
5'  uguug  g c cgc cgcuggguc agugguucu aaca uuca caguu c  u
    |||||  | | ||| ||||||||| ||||||||| |||| |||| ||||| |   
3'  gcgac  c g gcg gcggcccag ucaccagga uugu aagu guuaa g  a
   a     ag g c   g         a         u    a    -     c cg 
Get sequence
Deep sequencing
11444 reads, 2.75e+03 reads per million, 60 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].

Genome context
Coordinates (GRCh38) Overlapping transcripts
chr14: 104117405-104117514 [+]
sense
OTTHUMT00000414859 ; KLC1-021; intron 1
OTTHUMT00000402947 ; KLC1-001; intron 1
OTTHUMT00000402944 ; KLC1-003; intron 1
OTTHUMT00000414860 ; KLC1-022; intron 1
OTTHUMT00000402945 ; KLC1-002; intron 1
OTTHUMT00000414861 ; KLC1-009; intron 1
OTTHUMT00000414862 ; KLC1-008; intron 1
OTTHUMT00000402946 ; KLC1-005; intron 1
OTTHUMT00000414863 ; KLC1-016; intron 1
OTTHUMT00000414864 ; KLC1-010; intron 1
OTTHUMT00000414866 ; KLC1-011; intron 1
OTTHUMT00000414867 ; KLC1-013; intron 1
OTTHUMT00000414868 ; KLC1-020; intron 1
OTTHUMT00000402950 ; KLC1-004; intron 1
OTTHUMT00000414869 ; KLC1-017; intron 1
OTTHUMT00000414871 ; KLC1-015; intron 1
OTTHUMT00000402943 ; RP11-73M18.2-001; intron 4
ENST00000557172 ; KLC1-021; intron 1
ENST00000348520 ; KLC1-001; intron 1
ENST00000380038 ; KLC1-003; intron 1
ENST00000555467 ; KLC1-022; intron 1
ENST00000389744 ; KLC1-002; intron 1
ENST00000557575 ; KLC1-009; intron 1
ENST00000553286 ; KLC1-008; intron 1
ENST00000347839 ; KLC1-005; intron 1
ENST00000555836 ; KLC1-016; intron 1
ENST00000334553 ; KLC1-010; intron 1
ENST00000246489 ; KLC1-011; intron 1
ENST00000554228 ; KLC1-013; intron 1
ENST00000557450 ; KLC1-020; intron 1
ENST00000452929 ; KLC1-004; intron 1
ENST00000554280 ; KLC1-017; intron 1
ENST00000445352 ; KLC1-015; intron 1
ENST00000472726 ; RP11-73M18.2-001; intron 4
Clustered miRNAs
< 10kb from hsa-mir-203a
hsa-mir-203achr14: 104117405-104117514 [+]
hsa-mir-203bchr14: 104117418-104117503 [-]
Database links

Mature sequence hsa-miR-203a-5p

Accession MIMAT0031890
Sequence

27 - 

agugguucuuaacaguucaacaguu

 - 51

Get sequence
Deep sequencing116 reads, 17 experiments
Evidence not experimental
Predicted targets

Mature sequence hsa-miR-203a-3p

Accession MIMAT0000264
Previous IDshsa-miR-203a
Sequence

65 - 

gugaaauguuuaggaccacuag

 - 86

Get sequence
Deep sequencing2458 reads, 55 experiments
Evidence experimental; cloned [2]
Validated targets
Predicted targets

References

1
PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
2
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3
PMID:17622355 "MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?" Sonkoly E, Wei T, Janson PC, Saaf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Stahle M, Pivarcsi A PLoS One. 2:e610(2007).