Stem-loop sequence hsa-mir-129-1

Previous IDshsa-mir-129;hsa-mir-129a
Symbol HGNC:MIR129-1
DescriptionHomo sapiens miR-129-1 stem-loop
Gene family MIPF0000073; mir-129
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-129_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-129 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. This microRNA was first experimentally characterised in mouse and homologues have since been discovered in several other species, such as humans, rats and zebrafish. The mature sequence is excised by the Dicer enzyme from the 5' arm of the hairpin. It was elucidated by Calin et al. that miR-129-1 is located in a fragile site region of the human genome near a specific site, FRA7H in chromosome 7q32, which is a site commonly deleted in many cancers. miR-129-2 is located in 11p11.2.

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       -       c   cu      g   uu cu  c 
5' ggau cuuuuug ggu  gggcuu cug  c  cu a
   |||| ||||||| |||  |||||| |||  |  ||  
3' ucua gaaaaac cca  cccgaa gac  g  ga a
       u       c   uu      g   -u au  c 
Get sequence
Deep sequencing
9630 reads, 1.18e+03 reads per million, 50 experiments
Confidence Annotation confidence: high
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This miRNA sequence was predicted based on homology to a verified miRNA cloned from mouse cerebellum [1]. Expression of this miRNA was subsequently verified in a human osteoblast sarcoma cell line [2]. Reference [2] named the human/mouse conserved sequence miR-129b, but subsequent genome searches suggest that the same mature sequence may be expressed from two predicted hairpin precursors in both human (this entry and MI0000473) and mouse (MI0000222 and MI0000585). Landgraf et al. show that the 5' product of mir-129-1 (this entry) is the predominant one, whereas both 5' and 3' products are significantly expressed from mir-129-2 (MI0000585) [3].

Genome context
Coordinates (GRCh38) Overlapping transcripts
chr7: 128207872-128207943 [+]
OTTHUMT00000350446 ; RP11-274B21.1-001; intron 1
OTTHUMT00000468355 ; RP11-274B21.1-002; intron 2
ENST00000479267 ; RP11-274B21.1-001; intron 1
ENST00000605862 ; RP11-274B21.1-002; intron 2
Database links

Mature sequence hsa-miR-129-5p

Accession MIMAT0000242
Previous IDshsa-miR-129

5 - 


 - 25

Get sequence
Deep sequencing6037 reads, 39 experiments
Evidence experimental; cloned [2-3]
Validated targets
Predicted targets

Mature sequence hsa-miR-129-1-3p

Accession MIMAT0004548
Previous IDshsa-miR-129*

49 - 


 - 70

Get sequence
Deep sequencing1561 reads, 33 experiments
Evidence experimental; cloned [3]
Predicted targets


PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
PMID:12554859 "New microRNAs from mouse and human" Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T RNA. 9:175-179(2003).
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).