| Community annotation |
This text is a summary paragraph taken from the Wikipedia
entry entitled MiR-208. miRBase and Rfam
are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...
The text in this section is taken from the free, online
encyclopedia, Wikipedia. Anyone can edit a Wikipedia page. We hope
that experts on particular microRNA sequences will use the links to
Wikipedia below to edit the annotation of individual microRNAs, to add
information about function, evolution, discovery, and literature
references, for example. Any changes that you make will be visible in
Wikipedia immediately, and in miRBase within 24 hours.
Editing Wikipedia entries is straightforward. If you haven't
edited a page before, you might like to take a look at the following
Wikipedia help pages:
You can also create new pages at Wikipedia about microRNA families
that do not currently have specific entries there. Please let us know
if you do, so we can incorporate your annotation into miRBase, and
create the appropriate links from miRBase entries to the relevant
Wikipedia pages.
Please note, we're not responsible for the content of Wikipedia pages.
You can read more about miRBase, Wikipedia and community annotation on this blog post.
Please email us for
help or with comments about this community annotation initiative.
miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
In humans, the gene for miR-208 is located in an intron of MYH7.
Show Wikipedia entry
View @ Wikipedia
Edit Wikipedia entry
miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
In humans, the gene for miR-208 is located in an intron of MYH7.[3]
[edit] Function
miR-208 has been deemed a "myomiR"[3] as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133.[3] miR-208 is though to be dysregulated in various cardiovascular diseases.[4][5]
miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development.[3] It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.[6]
[edit] Applications
A preliminary study has shown a potential use in the prognosis of dilated cardiomyopathy.[7] Another application has been suggested as using plasma concentration of miR-208 as a biomarker of damaged cardiac muscle cells.[8]
[edit] References
- ^ Ambros, V (2001-12-28). "microRNAs: tiny regulators with great potential.". Cell 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Gregory, RI; Chendrimada, TP, Cooch, N, Shiekhattar, R (2005-11-18). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.". Cell 123 (4): 631–40. doi:10.1016/j.cell.2005.10.022. PMID 16271387.
- ^ a b c d Malizia, AP; Wang, DZ (2011 Mar-Apr). "MicroRNAs in cardiomyocyte development.". Wiley interdisciplinary reviews. Systems biology and medicine 3 (2): 183–90. doi:10.1002/wsbm.111. PMC 3058499. PMID 21305703. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3058499.
- ^ Cai, B; Pan, Z, Lu, Y (2010). "The roles of microRNAs in heart diseases: a novel important regulator.". Current medicinal chemistry 17 (5): 407–11. doi:10.2174/092986710790226129. PMID 20015039. (Subscription required)
- ^ Han, M; Toli, J, Abdellatif, M (2011 May). "MicroRNAs in the cardiovascular system.". Current opinion in cardiology 26 (3): 181–9. doi:10.1097/HCO.0b013e328345983d. PMID 21464712.
- ^ van Rooij, E; Sutherland, LB, Qi, X, Richardson, JA, Hill, J, Olson, EN (2007-04-27). "Control of stress-dependent cardiac growth and gene expression by a microRNA.". Science 316 (5824): 575–9. doi:10.1126/science.1139089. PMID 17379774.
- ^ Satoh, M; Minami, Y, Takahashi, Y, Tabuchi, T, Nakamura, M (2010 May). "Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy.". Journal of cardiac failure 16 (5): 404–10. doi:10.1016/j.cardfail.2010.01.002. PMID 20447577.
- ^ Ji, X; Takahashi, R, Hiura, Y, Hirokawa, G, Fukushima, Y, Iwai, N (2009 Nov). "Plasma miR-208 as a biomarker of myocardial injury.". Clinical chemistry 55 (11): 1944–9. doi:10.1373/clinchem.2009.125310. PMID 19696117.
[edit] Further reading
|
