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In molecular biology mir-145 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by a several mechanisms.
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In molecular biology mir-145 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by a several mechanisms.
Targets
MicroRNAs are involved in down regulation of a variety of target genes. Götte et al. have shown that experimental overexpression of mir-145 down regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin.[1] Larsson et al.[2] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.[3]
Role in cancer
miR-145 is hypothesised to be a tumor suppressor.[4] miR-145 has been shown to be down regulated in breast cancer.[1] miR-145 is also involved in colon cancer.[3][5]
References
- ^ a b Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S, Teng YH, Low JY, Ebnet K, Kiesel L, Yip GW (2010). "miR-145-dependent targeting of Junctional Adhesion Molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness.". Oncogene 29 (50): 6569–80. doi:10.1038/onc.2010.386. PMID 20818426.
- ^ Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, Arrondel C, Gerwins P, Kurschat C, Schermer B, Benzing T, Harvey SJ, Kreuger J, Lindahl P (2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1.". Genome Med 1 (11): 108. doi:10.1186/gm108. PMC 2808743. PMID 19917099.
- ^ a b Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, Hoffman AR, Hu JF, Ge S (2010). "Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene friend leukemia virus integration 1 gene.". Cancer 117 (1): 86–95. doi:10.1002/cncr.25522. PMC 2995010. PMID 20737575.
- ^ Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY (2009). "p53 represses c-Myc through induction of the tumor suppressor miR-145.". Proc Natl Acad Sci U S A 106 (9): 3207–12. doi:10.1073/pnas.0808042106. PMC 2651330. PMID 19202062.
- ^ Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M, Nenutil R, Vyzula R (2007). "Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer.". Oncology 72 (5-6): 397–402. doi:10.1159/000113489. PMID 18196926.
Further reading
- ^ Zhang J, Guo H, Qian G, Ge S, Ji H, Hu X, Chen W (2010). "MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network.". Mol Cancer 9: 211. doi:10.1186/1476-4598-9-211. PMC 2924312. PMID 20687965.
- ^ Zaman MS, Chen Y, Deng G, Shahryari V, Suh SO, Saini S, Majid S, Liu J, Khatri G, Tanaka Y, Dahiya R (2010). "The functional significance of microRNA-145 in prostate cancer.". Br J Cancer 103 (2): 256–64. doi:10.1038/sj.bjc.6605742. PMC 2906737. PMID 20588276.
- ^ Sachdeva M, Mo YY (2010). "miR-145-mediated suppression of cell growth, invasion and metastasis.". Am J Transl Res 2 (2): 170–80. PMC 2855636. PMID 20407606.
- ^ Kano M, Seki N, Kikkawa N, Fujimura L, Hoshino I, Akutsu Y, Chiyomaru T, Enokida H, Nakagawa M, Matsubara H (2010). "miR-145, miR-133a and miR-133b: Tumor suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma.". Int J Cancer 127: 2804. doi:10.1002/ijc.25284. PMID 20198616.
- ^ Chiyomaru T, Enokida H, Tatarano S, Kawahara K, Uchida Y, Nishiyama K, Fujimura L, Kikkawa N, Seki N, Nakagawa M (2010). "miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer.". Br J Cancer 102 (5): 883–91. doi:10.1038/sj.bjc.6605570. PMC 2833258. PMID 20160723.
- ^ Gregersen LH, Jacobsen AB, Frankel LB, Wen J, Krogh A, Lund AH (2010). "MicroRNA-145 targets YES and STAT1 in colon cancer cells.". In Kudla, Grzegorz. PLoS ONE 5 (1): e8836. doi:10.1371/journal.pone.0008836. PMC 2809101. PMID 20098684.
- ^ Sachdeva M, Mo YY (2010). "MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1.". Cancer Res 70 (1): 378–87. doi:10.1158/0008-5472.CAN-09-2021. PMC 2805032. PMID 19996288.
- ^ Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genové G, Arrondel C, Gerwins P, Kurschat C, Schermer B, Benzing T, Harvey SJ, Kreuger J, Lindahl P (2009). "Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1.". Genome Med 1 (11): 108. doi:10.1186/gm108. PMC 2808743. PMID 19917099.
- ^ Ostenfeld MS, Bramsen JB, Lamy P, Villadsen SB, Fristrup N, Sørensen KD, Ulhøi B, Borre M, Kjems J, Dyrskjøt L, Orntoft TF (2010). "miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors.". Oncogene 29 (7): 1073–84. doi:10.1038/onc.2009.395. PMID 19915607.
- ^ Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, Hirst M, Hogge D, Marra M, Wells RA, Buckstein R, Lam W, Humphries RK, Karsan A (2010). "Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.". Nat Med 16 (1): 49–58. doi:10.1038/nm.2054. PMID 19898489.
- ^ Arndt GM, Dossey L, Cullen LM, Lai A, Druker R, Eisbacher M, Zhang C, Tran N, Fan H, Retzlaff K, Bittner A, Raponi M (2009). "Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer.". BMC Cancer 9: 374. doi:10.1186/1471-2407-9-374. PMC 2770572. PMID 19843336.
- ^ Zhang C (2009). "MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease.". Cell Cycle 8 (21): 3469–73. doi:10.4161/cc.8.21.9837. PMID 19829088.
- ^ Zeng L, Carter AD, Childs SJ (2009). "miR-145 directs intestinal maturation in zebrafish.". Proc Natl Acad Sci U S A 106 (42): 17793–8. doi:10.1073/pnas.0903693106. PMC 2764920. PMID 19805048.
- ^ Spizzo R, Nicoloso MS, Lupini L, Lu Y, Fogarty J, Rossi S, Zagatti B, Fabbri M, Veronese A, Liu X, Davuluri R, Croce CM, Mills G, Negrini M, Calin GA (2010). "miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells.". Cell Death Differ 17 (2): 246–54. doi:10.1038/cdd.2009.117. PMID 19730444.
- ^ Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN (2009). "MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury.". Genes Dev 23 (18): 2166–78. doi:10.1101/gad.1842409. PMC 2751981. PMID 19720868.
- ^ Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D (2009). "miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.". Nature 460 (7256): 705–10. doi:10.1038/nature08195. PMC 2769203. PMID 19578358.
- ^ Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, Lu Q, Deitch EA, Huo Y, Delphin ES, Zhang C (2009). "MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation.". Circ Res 105 (2): 158–66. doi:10.1161/CIRCRESAHA.109.197517. PMC 2728297. PMID 19542014.
- ^ Cho WC, Chow AS, Au JS (2009). "Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation.". Eur J Cancer 45 (12): 2197–206. doi:10.1016/j.ejca.2009.04.039. PMID 19493678.
- ^ Chivukula RR, Mendell JT (2009). "Abate and switch: miR-145 in stem cell differentiation.". Cell 137 (4): 606–8. doi:10.1016/j.cell.2009.04.059. PMID 19450510.
- ^ Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS (2009). "MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.". Cell 137 (4): 647–58. doi:10.1016/j.cell.2009.02.038. PMID 19409607.
- ^ La Rocca G, Badin M, Shi B, Xu SQ, Deangelis T, Sepp-Lorenzinoi L, Baserga R (2009). "Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway.". J Cell Physiol 220 (2): 485–91. doi:10.1002/jcp.21796. PMID 19391107.
- ^ Wang S, Bian C, Yang Z, Bo Y, Li J, Zeng L, Zhou H, Zhao RC (2009). "miR-145 inhibits breast cancer cell growth through RTKN.". Int J Oncol 34 (5): 1461–6. PMID 19360360.
- ^ Zheng, L; Pu, J; Qi, T; Qi, M; Li, D; Xiang, X; Huang, K; Tong, Q (Dec 11, 2012). "microRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis and angiogenesis of gastric cancer cells.". Molecular cancer research : MCR 11 (2): 182–93. doi:10.1158/1541-7786.MCR-12-0534. PMID 23233482.
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