Stem-loop sequence mmu-mir-127

Accession

MI0000154 (change log)

Symbol

MGI:Mir127

Description

Mus musculus miR-127 stem-loop

Gene family

MIPF0000080; mir-127

Literature search

64 open access papers mention mmu-mir-127
(602 sentences)

Stem-loop

   ----      ugcug         g  c      --  a 
5'     ccagcc     aagcucaga gg ucugau  uc g
       ||||||     ||||||||| || ||||||  || a
3'     ggucgg     uucgagucu cc aggcua  ag a
   ggcu      -----         g  u      cu  a 

Deep sequencing

5656958 reads, 7.23e+03 reads per million, 103 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [6].

Genome context

• Coordinates (GRCm38; GCA_000001635.2): chr12: 109592846-109592915 [+]
• Overlapping transcripts:

  sense

  ENSMUST00000093568 ; Mir127-201; exon 1

  antisense

  ENSMUST00000149046 ; Rtl1-201; exon 2

Clustered miRNAs

< 10kb from mmu-mir-127

• mmu-mir-337: chr12: 109585789-109585885 [+]
• mmu-mir-3544: chr12: 109585813-109585873 [-]
• mmu-mir-540: chr12: 109586080-109586146 [+]
• mmu-mir-665: chr12: 109586314-109586407 [+]
• mmu-mir-3070-1: chr12: 109587943-109588031 [+]
• mmu-mir-3070-2: chr12: 109588592-109588680 [+]
• mmu-mir-431: chr12: 109590447-109590537 [+]
• mmu-mir-433: chr12: 109591715-109591838 [+]
• mmu-mir-127: chr12: 109592846-109592915 [+]
• mmu-mir-434: chr12: 109594506-109594599 [+]
• mmu-mir-432: chr12: 109594956-109595030 [+]
• mmu-mir-3071: chr12: 109595318-109595397 [-]
• mmu-mir-136: chr12: 109595327-109595388 [+]

Database links

• EntrezGene:Mir127
• MGI:Mir127
• RNAcentral:URS0000341906_10090
• miRBase Tracker:MI0000154

Mature sequence mmu-miR-127-5p

• Accession: MIMAT0004530
• Previous IDs: mmu-miR-127*
• Sequence: 9 - cugaagcucagagggcucugau - 30
• Deep sequencing: 72899 reads, 87 experiments
• Evidence: experimental; cloned [6], Illumina [7-8]
• Database links:
  • RNAcentral:URS00000A33DB_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-127-5p
  • miRDB:mmu-miR-127-5p
  • microrna.org:mmu-miR-127-5p

Mature sequence mmu-miR-127-3p

• Accession: MIMAT0000139
• Previous IDs: mmu-miR-127
• Sequence: 43 - ucggauccgucugagcuuggcu - 64
• Deep sequencing: 5584050 reads, 102 experiments
• Evidence: experimental; cloned [1,3,5-6], PCR [4], Illumina [7-8]
• Database links:
  • RNAcentral:URS00001E3DAA_10090
• Predicted targets:
  • TargetScanVert:mmu-miR-127-3p
  • miRDB:mmu-miR-127-3p
  • microrna.org:mmu-miR-127-3p

References

1. PMID:12007417 "Identification of tissue-specific microRNAs from mouse" Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T Curr Biol. 12:735-739(2002).
2. PMID:12919684 "Embryonic stem cell-specific MicroRNAs" Houbaviy HB, Murray MF, Sharp PA Dev Cell. 5:351-358(2003).
3. PMID:15538371 "A pancreatic islet-specific microRNA regulates insulin secretion" Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M Nature. 432:226-230(2004).
4. PMID:15854907 "RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus" Davis E, Caiment F, Tordoir X, Cavaille J, Ferguson-Smith A, Cockett N, Georges M, Charlier C Curr Biol. 15:743-749(2005).
5. PMID:16766679 "Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes" Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H Genes Dev. 20:1732-1743(2006).
6. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
7. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
8. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).