Stem-loop sequence hsa-mir-16-2

AccessionMI0000115 (change log)
Previous IDshsa-mir-16-3
Symbol HGNC:MIR16-2
DescriptionHomo sapiens miR-16-2 stem-loop
Gene family MIPF0000006; mir-15
Literature search

682 open access papers mention hsa-mir-16-2
(3184 sentences)

Stem-loop
     uc    cu         ua        c  ag   aau 
5' gu  cacu  agcagcacg  aauauugg gu  uga   a
   ||  ||||  |||||||||  |||||||| ||  |||    
3' ca  guga  ucgucgugu  uuauaacc ca  auu   u
     gu    uu         ca        a  -a   aua 
Get sequence
Deep sequencing
3881017 reads, 1.04e+04 reads per million, 159 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Comments

This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MI0000070). The sequence was previously named mir-16-3 here and in references [1] and [2].

Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chr3: 160404745-160404825 [+]
intergenic
Clustered miRNAs
< 10kb from hsa-mir-16-2
hsa-mir-15bchr3: 160404588-160404685 [+]
hsa-mir-16-2chr3: 160404745-160404825 [+]
Database links

Mature sequence hsa-miR-16-5p

Accession MIMAT0000069
Previous IDshsa-miR-16
Sequence

10 - 

uagcagcacguaaauauuggcg

 - 31

Get sequence
Deep sequencing7830515 reads, 159 experiments
Evidence experimental; cloned [1,3-4,6-8], Northern [3]
Database links
Predicted targets

Mature sequence hsa-miR-16-2-3p

Accession MIMAT0004518
Previous IDshsa-miR-16-2*
Sequence

53 - 

ccaauauuacugugcugcuuua

 - 74

Get sequence
Deep sequencing12590 reads, 157 experiments
Evidence experimental; cloned [7]
Database links
Predicted targets

References

1
PMID:11914277 "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G Genes Dev. 16:720-728(2002).
2
PMID:12624257 "Vertebrate microRNA genes" Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP Science. 299:1540(2003).
3
PMID:11679670 "Identification of novel genes coding for small expressed RNAs" Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T Science. 294:853-858(2001).
4
PMID:15183728 "Human embryonic stem cells express a unique set of microRNAs" Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS Dev Biol. 270:488-498(2004).
5
PMID:14573789 "Reduced accumulation of specific microRNAs in colorectal neoplasia" Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ Mol Cancer Res. 1:882-891(2003).
6
PMID:15325244 "Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells" Kasashima K, Nakamura Y, Kozu T Biochem Biophys Res Commun. 322:403-410(2004).
7
PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
8
PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).