Stem-loop sequence hsa-mir-16-1

Previous IDshsa-mir-16-13;hsa-mir-16
Symbol HGNC:MIR16-1
DescriptionHomo sapiens miR-16-1 stem-loop
Gene family MIPF0000006; mir-15
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-16_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-16 microRNA precursor family is a group of related small non-coding RNA genes that regulates gene expression. miR-16, miR-15, mir-195 and miR-457 are related microRNA precursor sequences from the mir-15 gene family. This microRNA family appears to be vertebrate specific and its members have been predicted or experimentally validated in a wide range of vertebrate species (MIPF0000006).

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Get sequence
Deep sequencing
36647 reads, 3.93e+03 reads per million, 74 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?

Human miR-16 has been cloned by independent groups [1,2]. This precursor sequence maps to chromosome 13, and was named mir-16 in [1] and mir-16-precursor-13 in [2]. Lim et al. reported 2 identical chromosome 13 loci, which appear to map to the same locus in subsequent genome assemblies. This gene and miR-15a are clustered within 0.5 kb at 13q14. This region has been shown to be deleted in more than half of B cell chronic lymphocytic leukemias (CLL). Both miR-15a and miR-16 are deleted or down-regulated in more than two thirds of CLL cases [3]. A second putative mir-16 hairpin precursor is located on chromosome 3 (MI0000738).

Genome context
Coordinates (GRCh38) Overlapping transcripts
chr13: 50048973-50049061 [-]
OTTHUMT00000044927 ; SETDB2-003; intron 5
OTTHUMT00000044925 ; SETDB2-001; intron 6
ENST00000258672 ; SETDB2-003; intron 5
ENST00000354234 ; SETDB2-201; intron 5
ENST00000317257 ; SETDB2-001; intron 6
Clustered miRNAs
< 10kb from hsa-mir-16-1
hsa-mir-15achr13: 50049119-50049201 [-]
hsa-mir-16-1chr13: 50048973-50049061 [-]
Database links

Mature sequence hsa-miR-16-5p

Accession MIMAT0000069
Previous IDshsa-miR-16

14 - 


 - 35

Get sequence
Deep sequencing3244 reads, 64 experiments
Evidence experimental; cloned [1,3-4,6-8], Northern [3]
Validated targets
Predicted targets

Mature sequence hsa-miR-16-1-3p

Accession MIMAT0004489
Previous IDshsa-miR-16-1*

56 - 


 - 77

Get sequence
Deep sequencing77 reads, 19 experiments
Evidence experimental; cloned [8]
Validated targets
Predicted targets


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