Stem-loop sequence MI0000068

Accession

MI0000068

ID

hsa-let-7f-2

Symbol

HGNC:MIRLET7F2

Description

Homo sapiens let-7f-2 stem-loop

Stem-loop

u      u   gu                uuagggucauac 
 guggga gag  aguagauuguauaguu            c
 |||||| |||  ||||||||||||||||             
 cacccu uuc  ucaucugacauaucaa            c
g      -   ug                uagagguucuac 

Genome context

• Coordinates (GRCh37): X: 53584153-53584235 [-]
• Overlapping transcripts:

  sense

  OTTHUMT00000056767 ; HUWE1-002; intron 34

  OTTHUMT00000056766 ; HUWE1-001; intron 59

  ENST00000427052 ; HUWE1-002; intron 34

  ENST00000342160 ; HUWE1-001; intron 59

  ENST00000375220 ; HUWE1-203; intron 60

  ENST00000262854 ; HUWE1-201; intron 60

  ENST00000276009 ; HUWE1-202; intron 60

View flanking features

Clustered miRNAs

< 10kb from hsa-let-7f-2

• hsa-let-7f-2: X: 53584153-53584235 [-]
• hsa-mir-98: X: 53583184-53583302 [-]

Database links

• EMBL: AJ421732;HSA421732
• RFAM: RF00027;let-7
• HGNC: 31484;MIRLET7F2
• ENTREZGENE: 406889;MIRLET7F2

Gene family

MIPF0000002; let-7

Mature sequence MIMAT0000067

• Accession: MIMAT0000067
• ID: hsa-let-7f
• Sequence: 8 - ugagguaguagauuguauaguu - 29
• Evidence: experimental; cloned [1,3-5], Northern [1]
• Predicted targets:
  • MICROCOSM:hsa-let-7f
  • TARGETSCAN:hsa-let-7f
  • PICTAR-VERT:hsa-let-7f

Minor miR* sequence MIMAT0004487

• Accession: MIMAT0004487
• ID: hsa-let-7f-2*
• Sequence: 58 - cuauacagucuacugucuuucc - 79
• Evidence: experimental; cloned [4]
• Predicted targets:
  • MICROCOSM:hsa-let-7f-2*
  • TARGETSCAN:hsa-let-7f-2*

References

1. "Identification of novel genes coding for small expressed RNAs" Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T Science. 294:853-858(2001).
2. "Reduced accumulation of specific microRNAs in colorectal neoplasia" Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ Mol Cancer Res. 1:882-891(2003).
3. "Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells" Kasashima K, Nakamura Y, Kozu T Biochem Biophys Res Commun. 322:403-410(2004).
4. "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
5. "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).