Stem-loop sequence hsa-let-7c

AccessionMI0000064 (change log)
Previous IDshsa-let-7cL
DescriptionHomo sapiens let-7c stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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     a      uu   g   u             ua  g ua a 
5' gc uccggg  gag uag agguuguaugguu  ga u  c c
   || ||||||  ||| ||| |||||||||||||  || |  | c
3' cg agguuc  uuc auc uccaacaugucaa  uu a  g c
     -      cu   g   u             --  g gg u 
Get sequence
Deep sequencing
30434967 reads, 1.81e+05 reads per million, 77 experiments
Confidence Annotation confidence: high
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Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chr21: 16539828-16539911 [+]
Clustered miRNAs
< 10kb from hsa-let-7c
hsa-mir-99achr21: 16539089-16539169 [+]
hsa-let-7cchr21: 16539828-16539911 [+]
Database links

Mature sequence hsa-let-7c-5p

Accession MIMAT0000064

11 - 


 - 32

Get sequence
Deep sequencing30434165 reads, 77 experiments
Evidence experimental; cloned [1-4], Northern [1], Illumina [5-6]
Database links
Predicted targets

Mature sequence hsa-let-7c-3p

Accession MIMAT0026472

56 - 


 - 77

Get sequence
Deep sequencing668 reads, 45 experiments
Evidence experimental; Illumina [6]
Database links
Predicted targets


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PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).