Stem-loop sequence hsa-let-7a-2

AccessionMI0000061 (change log)
Previous IDshsa-let-7a-2L
DescriptionHomo sapiens let-7a-2 stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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      uu   g   u             uagaa ua a 
5' agg  gag uag agguuguauaguu     u  c u
   |||  ||| ||| |||||||||||||     |  | c
3' ucc  uuc auc uccgacaugucaa     a  g a
      -u   g   c             --uag gg a 
Get sequence
Deep sequencing
32044120 reads, 1.88e+05 reads per million, 77 experiments
Confidence Annotation confidence: high
Feedback: Do you believe this miRNA is real?
Genome context
Coordinates (GRCh38; GCA_000001405.15) Overlapping transcripts
chr11: 122146522-122146593 [-]
OTTHUMT00000387568 ; RP11-820L6.1-006; intron 2
OTTHUMT00000387569 ; RP11-820L6.1-008; intron 2
OTTHUMT00000387570 ; RP11-820L6.1-007; intron 2
OTTHUMT00000387551 ; RP11-820L6.1-001; intron 3
ENST00000529804 ; RP11-820L6.1-006; intron 2
ENST00000529733 ; RP11-820L6.1-008; intron 2
ENST00000528381 ; RP11-820L6.1-007; intron 2
ENST00000527474 ; RP11-820L6.1-001; intron 3
Clustered miRNAs
< 10kb from hsa-let-7a-2
hsa-mir-100chr11: 122152229-122152308 [-]
hsa-mir-10526chr11: 122152103-122152156 [-]
hsa-let-7a-2chr11: 122146522-122146593 [-]
Database links

Mature sequence hsa-let-7a-5p

Accession MIMAT0000062
Previous IDshsa-let-7a

5 - 


 - 26

Get sequence
Deep sequencing96044809 reads, 77 experiments
Evidence experimental; cloned [1-3,5-8], Northern [1], Illumina [9]
Database links
Predicted targets

Mature sequence hsa-let-7a-2-3p

Accession MIMAT0010195
Previous IDshsa-let-7a-2*

50 - 


 - 71

Get sequence
Deep sequencing103 reads, 30 experiments
Evidence experimental; qRT-PCR [9]
Database links
Predicted targets


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