Stem-loop sequence hsa-let-7a-1

Previous IDshsa-let-7a-1L
DescriptionHomo sapiens let-7a-1 stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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        u   gu                uuagggucacac 
5' uggga gag  aguagguuguauaguu            c
   ||||| |||  ||||||||||||||||            c
3' auccu uuc  ucaucuaacauaucaa            a
        -   ug                uagagggucacc 
Get sequence
Deep sequencing
5511665 reads, 4.85e+04 reads per million, 82 experiments
Confidence Annotation confidence: high
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let-7a-3p cloned in [6] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.

Genome context
Coordinates (GRCh38) Overlapping transcripts
chr9: 94175957-94176036 [+]
OTTHUMT00000053038 ; NFIL3-001; intron 1
ENST00000297689 ; NFIL3-001; intron 1
Clustered miRNAs
< 10kb from hsa-let-7a-1
hsa-let-7a-1chr9: 94175957-94176036 [+]
hsa-let-7f-1chr9: 94176347-94176433 [+]
hsa-let-7dchr9: 94178834-94178920 [+]
Database links

Mature sequence hsa-let-7a-5p

Accession MIMAT0000062
Previous IDshsa-let-7a

6 - 


 - 27

Get sequence
Deep sequencing125915 reads, 71 experiments
Evidence experimental; cloned [1-3,5-8], Northern [1], Illumina [9]
Validated targets
Predicted targets

Mature sequence hsa-let-7a-3p

Accession MIMAT0004481
Previous IDshsa-let-7a*

57 - 


 - 77

Get sequence
Deep sequencing1605 reads, 47 experiments
Evidence experimental; cloned [6]
Predicted targets


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PMID:17616659 "Patterns of known and novel small RNAs in human cervical cancer" Lui WO, Pourmand N, Patterson BK, Fire A Cancer Res. 67:6031-6043(2007).
PMID:17989717 "Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis" Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A Leukemia. 22:330-338(2008).